Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus
Refractory Status Epilepticus
About this trial
This is an interventional other trial for Refractory Status Epilepticus focused on measuring Status Epilepticus, Epilepticus, Epilepsy, Perampanel, Clinical trial for epilepsy, Epilepsy treatment, Seizure, seizure treatment, generalized tonic-clonic seizures, focal seizures, Refractory status epilepticus, (RSE), fycompa
Eligibility Criteria
Inclusion Criteria: Adults patients equal or greater than 18 years Patients in RSE that require IV anesthetic infusions. Note: RSE is defined as status epilepticus that fails to terminate after an adequate dose of benzodiazepines (1st line agents) and an AED (2nd line agent). Adequate doses have been defined in the screening (below). Patients taking oral contraception who will be on the study long term should be informed about additional alternative methods of contraception. Exclusion Criteria: Childbearing potential female who has a positive pregnancy test result or is otherwise known to be pregnant. Hypoglycemia or hyperglycemia induced seizures Mild, moderate or severe hepatic impairment Severe renal impairment or on hemodialysis History of psychiatric illness or suicidal behavior/ideation Previous or current use of PMP Known severe allergy to any AED Anoxic brain injury as etiology of status epilepticus Use caution in patients taking moderate and strong CYP3A4 Inducers (including carbamazepine, oxcarbazepine, and phenytoin) Patients on other forms of strong CYP3A4 (e.g. Rifampin, St John's Wart, etc).
Sites / Locations
- Wayne State University
Arms of the Study
Arm 1
Experimental
Single arm prospective study
Adults patients equal or greater than 18 years Patients in RSE that require IV anesthetic infusions. Note: RSE is defined as status epilepticus that fails to terminate after an adequate dose of benzodiazepines (1st line agents) and an AED (2nd line agent). Adequate doses have been defined in the screening (below). Patients taking oral contraception who will be on the study long term should be informed about additional alternative methods of contraception.