The REBUILD Trial: Closure of the Abdominal Wall

Inclusion Criteria: Patient is 22-80 years of age Patient is undergoing a midline laparotomy procedure Patient is able to provide written informed consent Patient is able and willing to comply with all study requirements Exclusion Criteria: Patient has BMI > 40 Patients with available imaging measuring abdominal wall thickness < 5.7 mm or > 16.5 mm Patient is scheduled for a palliative procedure or has a life expectancy of less than 12-months Patient has mesh at the site of deployment Patient has an ostomy within the planned midline closure site (4 cm either side of midline) Patient has a CDC wound classification of Class IV Patient has devitalized tissue present at the intended surgical site Patient has any co-morbid conditions determined by the investigator to place them at a high risk of complications (e.g., severe cardiovascular disease, congestive heart failure NYHA Class III or IV, end-stage renal failure, liver cirrhosis, connective tissue disorder, poorly managed diabetes) Patient is on any medication that the investigator determines creates a high risk for complications (e.g., antithrombotic, steroid, IV chemotherapy, immunosuppressive agent) Patient has history of radiation therapy targeting the abdominal wall Patient is participating in a concurrent investigational medical device study Patient is pregnant or planning on becoming pregnant during the study period Patient has a history of psychological condition, drug, or alcohol misuse which may interfere with their ability to be compliant with post-operative visits