VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease (Harmony-CD)
Crohn Disease
About this trial
This is an interventional treatment trial for Crohn Disease focused on measuring VTX958, Harmony, Crohn's disease, TYK2
Eligibility Criteria
Inclusion Criteria: Men or women, 18 to 75 years of age, inclusive, at the time of consent Capable of giving signed informed consent Documented diagnosis of CD ≥ 3 months prior to Day 1. The diagnosis of CD must be confirmed by clinical, endoscopic, and histologic evidence. Moderately to severely active CD Exclusion Criteria: Current diagnosis of ulcerative colitis, indeterminate colitis, microscopic colitis, ischemic colitis, or infectious colitis Presence of a stoma or ileoanal pouch Presence of currently known complications of CD such as symptomatic bowel stricture(s) and >2 missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, left and sigmoid colon, and rectum, fulminant colitis, toxic megacolon or any other manifestation that may require surgery or hospitalization Known diagnosis of short gut or bowel syndrome Previous exposure to VTX958 or any other TYK2 inhibitor (eg, deucravacitinib) in any study
Sites / Locations
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Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
VTX958 Dose A
VTX958 Dose B
VTX958 Placebo