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VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease (Harmony-CD)

Primary Purpose

Crohn Disease

Status
Recruiting
Phase
Phase 2
Locations
International
Study Type
Interventional
Intervention
VTX958
VTX958
VTX958 Placebo
Sponsored by
Ventyx Biosciences, Inc
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Crohn Disease focused on measuring VTX958, Harmony, Crohn's disease, TYK2

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Men or women, 18 to 75 years of age, inclusive, at the time of consent Capable of giving signed informed consent Documented diagnosis of CD ≥ 3 months prior to Day 1. The diagnosis of CD must be confirmed by clinical, endoscopic, and histologic evidence. Moderately to severely active CD Exclusion Criteria: Current diagnosis of ulcerative colitis, indeterminate colitis, microscopic colitis, ischemic colitis, or infectious colitis Presence of a stoma or ileoanal pouch Presence of currently known complications of CD such as symptomatic bowel stricture(s) and >2 missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, left and sigmoid colon, and rectum, fulminant colitis, toxic megacolon or any other manifestation that may require surgery or hospitalization Known diagnosis of short gut or bowel syndrome Previous exposure to VTX958 or any other TYK2 inhibitor (eg, deucravacitinib) in any study

Sites / Locations

  • Local Site # 840105Recruiting
  • Local Site # 840109Recruiting
  • Local Site # 840124Recruiting
  • Local Site # 840104Recruiting
  • Local Site # 840108Recruiting
  • Local Site # 840125Recruiting
  • Local Site # 840112Recruiting
  • Local Site # 840115Recruiting
  • Local Site # 840107Recruiting
  • Local Site # 840119Recruiting
  • Local Site # 840127Recruiting
  • Local Site # 840113Recruiting
  • Local Site # 840117Recruiting
  • Local Site # 840118Recruiting
  • Local Site # 840116Recruiting
  • Local Site # 840121Recruiting
  • Local Site # 840122Recruiting
  • Local Site # 840106Recruiting
  • Local Site # 840123Recruiting
  • Local Site # 840111Recruiting
  • Local Site # 840103Recruiting
  • Local Site # 840110Recruiting
  • Local Site # 840114Recruiting
  • Local Site # 840102Recruiting
  • Local Site # 840101Recruiting
  • Local Site # 840126Recruiting
  • Local Site # 036106Recruiting
  • Local Site # 036103Recruiting
  • Local Site # 036104Recruiting
  • Local Site # 036101Recruiting
  • Local Site # 036102Recruiting
  • Local Site # 036105Recruiting
  • Local Site # 076104Recruiting
  • Local Site # 076106Recruiting
  • Local Site # 076101Recruiting
  • Local Site # 076103Recruiting
  • Local Site # 076105Recruiting
  • Local Site # 100102Recruiting
  • Local Site # 100103Recruiting
  • Local Site # 100101Recruiting
  • Local Site # 124103Recruiting
  • Local Site # 124104Recruiting
  • Local Site # 124101Recruiting
  • Local Site # 124102Recruiting
  • Local Site # 203106Recruiting
  • Local Site # 203102Recruiting
  • Local Site # 203104Recruiting
  • Local Site # 203103Recruiting
  • Local Site # 268105Recruiting
  • Local Site # 268103Recruiting
  • Local Site # 268101Recruiting
  • Local Site # 276102Recruiting
  • Local Site # 276105Recruiting
  • Local Site # 276106Recruiting
  • Local Site # 276104Recruiting
  • Local Site # 276107Recruiting
  • Local Site # 348101Recruiting
  • Local Site # 348102Recruiting
  • Local Site # 348106Recruiting
  • Local Site # 348103Recruiting
  • Local Site # 348105Recruiting
  • Local Site # 376103Recruiting
  • Local Site # 376108Recruiting
  • Local Site # 376105Recruiting
  • Local Site # 376107Recruiting
  • Local Site # 376101Recruiting
  • Local Site # 376102Recruiting
  • Local Site # 440101Recruiting
  • Local Site # 498101Recruiting
  • Local Site # 498102Recruiting
  • Local Site # 616116Recruiting
  • Local Site #616113Recruiting
  • Local Site # 616112Recruiting
  • Local Site # 616117Recruiting
  • Local Site # 616107Recruiting
  • Local Site # 616115Recruiting
  • Local Site # 616104Recruiting
  • Local Site # 616118Recruiting
  • Local Site # 616106Recruiting
  • Local Site # 616102Recruiting
  • Local Site # 616114Recruiting
  • Local Site # 616103Recruiting
  • Local Site # 616108Recruiting
  • Local Site # 616110Recruiting
  • Local Site # 616105Recruiting
  • Local Site # 616101Recruiting
  • Local Site # 703103Recruiting
  • Locla Site # 703101Recruiting
  • Local Site # 703104Recruiting
  • Local Site # 703102Recruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Placebo Comparator

Arm Label

VTX958 Dose A

VTX958 Dose B

VTX958 Placebo

Arm Description

Outcomes

Primary Outcome Measures

Change in mean Crohn's disease Activity Index (CDAI) score from baseline to week 12
Change in Mean CDAI (Crohn's disease Activity Index). CDAI is a weighted index comprising eight Crohn's Disease (CD)-related clinical and laboratory variables, to assess CD disease activity. Three of the variables, stool frequency, abdominal pain, and general well-being, are patient-reported measures recorded daily. The total CDAI score is calculated using the sum of each variable times the multiplier. The total score range of the CDAI is from 0 to 600.
The proportion of participants achieving endoscopic response at Week 12
SES-CD is an endoscopic grading system is used to assess CD disease activity. The SES-CD assesses 4 endoscopic variables: the size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each variable score ranging from 0 to 3. The total SES-CD score is calculated using the sum of all parameter scores in 5 segments: terminal ileum, right colon, transverse colon, left colon, and rectum.

Secondary Outcome Measures

Change from baseline in mean simple endoscopic score in Crohn's disease SES-CD at Week 12
Change from baseline in mean simple endoscopic score in Crohn's disease SED-CD at 12 weeks. The SES-CD is an endoscopic grading system is used to assess CD disease activity. The SES-CD assesses 4 endoscopic variables: the size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each variable score ranging from 0 to 3. The total SES-CD score is calculated using the sum of all parameter scores in 5 segments: terminal ileum, right colon, transverse colon, left colon, and rectum.
Proportion of participants achieving clinical remission at Week 12
Clinical remission is defined as a CDAI score < 150. CDAI is a weighted index comprising eight Crohn's Disease (CD)-related clinical and laboratory variables, to assess CD disease activity. Three of the variables, stool frequency, abdominal pain, and general well-being, are patient-reported measures recorded daily. The total CDAI score is calculated using the sum of each variable times the multiplier. The total score range of the CDAI is from 0 to 600.
Proportion of participants achieving patient-reported outcome 2 (PRO2) remission at Week 12
The proportion of participants achieving PRO2 remission at week 12. PRO2 remission is defined is an unweighted CDAI component of daily AP score ≤ 1 and unweighted CDAI component of daily average stool frequency (SF) score ≤ 3
Proportion of participants achieving clinical response at Week 12
Proportion of participants achieving clinical response at Week 12. A clinical response is defined as ≥ 100 points reduction from baseline in CDAI score or CDAI score < 150. CDAI is a weighted index comprising eight Crohn's Disease (CD)-related clinical and laboratory variables, to assess CD disease activity. Three of the variables, stool frequency, abdominal pain, and general well-being, are patient-reported measures recorded daily. The total CDAI score is calculated using the sum of each variable times the multiplier. The total score range of the CDAI is from 0 to 600.
Proportion of participants achieving both endoscopic response (outcome- measure # 2) and clinical remission (outcome measure # 4) at Week 12
Proportion of participants achieving both endoscopic response (as described in outcome measure 2) and clinical remission (as described in outcome measure 4) at Week 12.

Full Information

First Posted
January 5, 2023
Last Updated
October 8, 2023
Sponsor
Ventyx Biosciences, Inc
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1. Study Identification

Unique Protocol Identification Number
NCT05688852
Brief Title
VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease
Acronym
Harmony-CD
Official Title
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VTX958 in Participants With Moderately to Severely Active Crohn's Disease
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
December 22, 2022 (Actual)
Primary Completion Date
June 2024 (Anticipated)
Study Completion Date
May 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Ventyx Biosciences, Inc

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
This is a multicenter, randomized, double-blind placebo-controlled, parallel group study to evaluate the efficacy and safety of VTX958 in participants with moderately to severely active Crohn's Disease.
Detailed Description
This is a multicenter, randomized, double-blind placebo-controlled, parallel group study to evaluate the efficacy and safety of VTX958 in participants with moderately to severely active Crohn's Disease. Approximately 132 eligible patients will be randomized, and randomization will be stratified by prior use of biologics for the treatment of CD (yes/no). The study consists of a 30-day Screening Period, a 12-week double-blind Induction Treatment Period, a 40-week double-blind Maintenance Treatment Period, an Open-Label Extension (OLE) of up to 144 weeks, and a 30-day safety Follow-Up Period. The maximum duration of treatment will be 36 months, including the Induction, Maintenance, and OLE Periods. For all participants, a Follow-Up visit will be performed at 30 days after the last dose of study drug. Objectives Primary Objectives * Evaluate the efficacy of VTX958 in achieving reduction in Crohn's Disease Activity Index (CDAI) score and endoscopic response at the end of the Induction Period Secondary Objectives Evaluate the efficacy of VTX958 in inducing clinical and symptomatic response and remission at the end of the Induction Period Evaluate the efficacy of VTX958 in inducing endoscopic response and clinical remission at the end of the Induction Period

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Crohn Disease
Keywords
VTX958, Harmony, Crohn's disease, TYK2

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 2
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
The study will employ a double-blind design. Participants, Investigators, study center staff, persons performing the assessments, and the Sponsor are to remain blinded to the identity of the Induction and Maintenance Period treatment from the time of randomization until the interim database lock for the study
Allocation
Randomized
Enrollment
132 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
VTX958 Dose A
Arm Type
Experimental
Arm Title
VTX958 Dose B
Arm Type
Experimental
Arm Title
VTX958 Placebo
Arm Type
Placebo Comparator
Intervention Type
Drug
Intervention Name(s)
VTX958
Intervention Description
Dose A VTX958
Intervention Type
Drug
Intervention Name(s)
VTX958
Intervention Description
Dose B VTX958
Intervention Type
Drug
Intervention Name(s)
VTX958 Placebo
Intervention Description
Placebo
Primary Outcome Measure Information:
Title
Change in mean Crohn's disease Activity Index (CDAI) score from baseline to week 12
Description
Change in Mean CDAI (Crohn's disease Activity Index). CDAI is a weighted index comprising eight Crohn's Disease (CD)-related clinical and laboratory variables, to assess CD disease activity. Three of the variables, stool frequency, abdominal pain, and general well-being, are patient-reported measures recorded daily. The total CDAI score is calculated using the sum of each variable times the multiplier. The total score range of the CDAI is from 0 to 600.
Time Frame
During screening to week 12
Title
The proportion of participants achieving endoscopic response at Week 12
Description
SES-CD is an endoscopic grading system is used to assess CD disease activity. The SES-CD assesses 4 endoscopic variables: the size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each variable score ranging from 0 to 3. The total SES-CD score is calculated using the sum of all parameter scores in 5 segments: terminal ileum, right colon, transverse colon, left colon, and rectum.
Time Frame
During screening to week 12
Secondary Outcome Measure Information:
Title
Change from baseline in mean simple endoscopic score in Crohn's disease SES-CD at Week 12
Description
Change from baseline in mean simple endoscopic score in Crohn's disease SED-CD at 12 weeks. The SES-CD is an endoscopic grading system is used to assess CD disease activity. The SES-CD assesses 4 endoscopic variables: the size of ulcers, ulcerated surface, affected surface, and presence of narrowing. Each variable score ranging from 0 to 3. The total SES-CD score is calculated using the sum of all parameter scores in 5 segments: terminal ileum, right colon, transverse colon, left colon, and rectum.
Time Frame
During screening to week 12
Title
Proportion of participants achieving clinical remission at Week 12
Description
Clinical remission is defined as a CDAI score < 150. CDAI is a weighted index comprising eight Crohn's Disease (CD)-related clinical and laboratory variables, to assess CD disease activity. Three of the variables, stool frequency, abdominal pain, and general well-being, are patient-reported measures recorded daily. The total CDAI score is calculated using the sum of each variable times the multiplier. The total score range of the CDAI is from 0 to 600.
Time Frame
During screening to week 12
Title
Proportion of participants achieving patient-reported outcome 2 (PRO2) remission at Week 12
Description
The proportion of participants achieving PRO2 remission at week 12. PRO2 remission is defined is an unweighted CDAI component of daily AP score ≤ 1 and unweighted CDAI component of daily average stool frequency (SF) score ≤ 3
Time Frame
During screening to week 12
Title
Proportion of participants achieving clinical response at Week 12
Description
Proportion of participants achieving clinical response at Week 12. A clinical response is defined as ≥ 100 points reduction from baseline in CDAI score or CDAI score < 150. CDAI is a weighted index comprising eight Crohn's Disease (CD)-related clinical and laboratory variables, to assess CD disease activity. Three of the variables, stool frequency, abdominal pain, and general well-being, are patient-reported measures recorded daily. The total CDAI score is calculated using the sum of each variable times the multiplier. The total score range of the CDAI is from 0 to 600.
Time Frame
During screening to week 12
Title
Proportion of participants achieving both endoscopic response (outcome- measure # 2) and clinical remission (outcome measure # 4) at Week 12
Description
Proportion of participants achieving both endoscopic response (as described in outcome measure 2) and clinical remission (as described in outcome measure 4) at Week 12.
Time Frame
During screening to week 12

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Men or women, 18 to 75 years of age, inclusive, at the time of consent Capable of giving signed informed consent Documented diagnosis of CD ≥ 3 months prior to Day 1. The diagnosis of CD must be confirmed by clinical, endoscopic, and histologic evidence. Moderately to severely active CD Exclusion Criteria: Current diagnosis of ulcerative colitis, indeterminate colitis, microscopic colitis, ischemic colitis, or infectious colitis Presence of a stoma or ileoanal pouch Presence of currently known complications of CD such as symptomatic bowel stricture(s) and >2 missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, left and sigmoid colon, and rectum, fulminant colitis, toxic megacolon or any other manifestation that may require surgery or hospitalization Known diagnosis of short gut or bowel syndrome Previous exposure to VTX958 or any other TYK2 inhibitor (eg, deucravacitinib) in any study
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Ventyx Clinical Trial Contact
Phone
888-411-5176
Ext
108
Email
ClinicalTrials@ventyxbio.com
Facility Information:
Facility Name
Local Site # 840105
City
Garden Grove
State/Province
California
ZIP/Postal Code
92845
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840109
City
Lancaster
State/Province
California
ZIP/Postal Code
93534
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840124
City
Kissimmee
State/Province
Florida
ZIP/Postal Code
34744
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840104
City
Miami
State/Province
Florida
ZIP/Postal Code
33165
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840108
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840125
City
Orlando
State/Province
Florida
ZIP/Postal Code
32825
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840112
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840115
City
Glenview
State/Province
Illinois
ZIP/Postal Code
60026
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840107
City
Gurnee
State/Province
Illinois
ZIP/Postal Code
60031
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840119
City
New Albany
State/Province
Indiana
ZIP/Postal Code
47150
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840127
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40218
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840113
City
Shreveport
State/Province
Louisiana
ZIP/Postal Code
71105
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840117
City
Chevy Chase
State/Province
Maryland
ZIP/Postal Code
20815
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840118
City
Rockville
State/Province
Maryland
ZIP/Postal Code
20850
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840116
City
Liberty
State/Province
Missouri
ZIP/Postal Code
64068
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840121
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840122
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43202
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840106
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73102
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840123
City
Myrtle Beach
State/Province
South Carolina
ZIP/Postal Code
29572
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840111
City
Garland
State/Province
Texas
ZIP/Postal Code
75044
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840103
City
Katy
State/Province
Texas
ZIP/Postal Code
77484
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840110
City
Lubbock
State/Province
Texas
ZIP/Postal Code
79410
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840114
City
Lubbock
State/Province
Texas
ZIP/Postal Code
79424
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840102
City
Southlake
State/Province
Texas
ZIP/Postal Code
76092
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840101
City
Tyler
State/Province
Texas
ZIP/Postal Code
75701
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 840126
City
West Jordan
State/Province
Utah
ZIP/Postal Code
84088
Country
United States
Individual Site Status
Recruiting
Facility Name
Local Site # 036106
City
Concord
ZIP/Postal Code
NSW 2139
Country
Australia
Individual Site Status
Recruiting
Facility Name
Local Site # 036103
City
Melbourne
ZIP/Postal Code
VIC 3004
Country
Australia
Individual Site Status
Recruiting
Facility Name
Local Site # 036104
City
Melbourne
ZIP/Postal Code
VIC 3011
Country
Australia
Individual Site Status
Recruiting
Facility Name
Local Site # 036101
City
Melbourne
ZIP/Postal Code
VIC 3065
Country
Australia
Individual Site Status
Recruiting
Facility Name
Local Site # 036102
City
Parkville
ZIP/Postal Code
VIC 3050
Country
Australia
Individual Site Status
Recruiting
Facility Name
Local Site # 036105
City
Perth
ZIP/Postal Code
WA 6150
Country
Australia
Individual Site Status
Recruiting
Facility Name
Local Site # 076104
City
Porto Alegre
State/Province
Rio Grande Do Su
ZIP/Postal Code
90035-903
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Local Site # 076106
City
Curitiba
ZIP/Postal Code
80230-130
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Local Site # 076101
City
Santo André
ZIP/Postal Code
09080-110
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Local Site # 076103
City
São Paulo
ZIP/Postal Code
04543-011
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Local Site # 076105
City
São Paulo
ZIP/Postal Code
076105
Country
Brazil
Individual Site Status
Recruiting
Facility Name
Local Site # 100102
City
Ruse
ZIP/Postal Code
7000
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Local Site # 100103
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Local Site # 100101
City
Sofia
ZIP/Postal Code
1784
Country
Bulgaria
Individual Site Status
Recruiting
Facility Name
Local Site # 124103
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6L 5L7
Country
Canada
Individual Site Status
Recruiting
Facility Name
Local Site # 124104
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
l1J 0C7
Country
Canada
Individual Site Status
Recruiting
Facility Name
Local Site # 124101
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6A 3B4
Country
Canada
Individual Site Status
Recruiting
Facility Name
Local Site # 124102
City
Woodbridge
State/Province
Ontario
ZIP/Postal Code
L4L 4Y7
Country
Canada
Individual Site Status
Recruiting
Facility Name
Local Site # 203106
City
Brno
ZIP/Postal Code
602 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Local Site # 203102
City
Brno
ZIP/Postal Code
636 00
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Local Site # 203104
City
Ostrava
ZIP/Postal Code
708 52
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Local Site # 203103
City
Ústí Nad Labem
ZIP/Postal Code
401 13
Country
Czechia
Individual Site Status
Recruiting
Facility Name
Local Site # 268105
City
Tbilisi
ZIP/Postal Code
0101
Country
Georgia
Individual Site Status
Recruiting
Facility Name
Local Site # 268103
City
Tbilisi
ZIP/Postal Code
0160
Country
Georgia
Individual Site Status
Recruiting
Facility Name
Local Site # 268101
City
Tbilisi
ZIP/Postal Code
0180
Country
Georgia
Individual Site Status
Recruiting
Facility Name
Local Site # 276102
City
Tuebingen
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
72076
Country
Germany
Individual Site Status
Recruiting
Facility Name
Local Site # 276105
City
Ulm
State/Province
Baden-Wuerttemberg
ZIP/Postal Code
89081
Country
Germany
Individual Site Status
Recruiting
Facility Name
Local Site # 276106
City
Duisburg
State/Province
North Rhine-Westphalia
ZIP/Postal Code
47055
Country
Germany
Individual Site Status
Recruiting
Facility Name
Local Site # 276104
City
Berlin
Country
Germany
Individual Site Status
Recruiting
Facility Name
Local Site # 276107
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Individual Site Status
Recruiting
Facility Name
Local Site # 348101
City
Budapest
ZIP/Postal Code
H-1033
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Local Site # 348102
City
Békéscsaba
ZIP/Postal Code
H-5600
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Local Site # 348106
City
Gyöngyös
ZIP/Postal Code
3200
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Local Site # 348103
City
Szekszárd
ZIP/Postal Code
H-7100
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Local Site # 348105
City
Tatabánya
ZIP/Postal Code
2800
Country
Hungary
Individual Site Status
Recruiting
Facility Name
Local Site # 376103
City
Ashkelon
ZIP/Postal Code
7830604
Country
Israel
Individual Site Status
Recruiting
Facility Name
Local Site # 376108
City
Haifa
ZIP/Postal Code
31048
Country
Israel
Individual Site Status
Recruiting
Facility Name
Local Site # 376105
City
Jerusalem
ZIP/Postal Code
9103102
Country
Israel
Individual Site Status
Recruiting
Facility Name
Local Site # 376107
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Individual Site Status
Recruiting
Facility Name
Local Site # 376101
City
Petah tikva
ZIP/Postal Code
49100
Country
Israel
Individual Site Status
Recruiting
Facility Name
Local Site # 376102
City
Reẖovot
ZIP/Postal Code
7661041
Country
Israel
Individual Site Status
Recruiting
Facility Name
Local Site # 440101
City
Vilnius
ZIP/Postal Code
LT-08661
Country
Lithuania
Individual Site Status
Recruiting
Facility Name
Local Site # 498101
City
Chisinau
ZIP/Postal Code
MD-2025
Country
Moldova, Republic of
Individual Site Status
Recruiting
Facility Name
Local Site # 498102
City
Chisinau
ZIP/Postal Code
MD-2025
Country
Moldova, Republic of
Individual Site Status
Recruiting
Facility Name
Local Site # 616116
City
Bydgoszcz
ZIP/Postal Code
85-794
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site #616113
City
Knurów
ZIP/Postal Code
44-190
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616112
City
Kraków
ZIP/Postal Code
31-501
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616117
City
Lublin
ZIP/Postal Code
20-412
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616107
City
Oświęcim
ZIP/Postal Code
32-600
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616115
City
Poznan
ZIP/Postal Code
61-293
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616104
City
Rzeszów
ZIP/Postal Code
35-326
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616118
City
Staszów
ZIP/Postal Code
28-200
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616106
City
Szczecin
ZIP/Postal Code
71-434
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616102
City
Warsaw
ZIP/Postal Code
00-728
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616114
City
Wrocław
ZIP/Postal Code
50-088
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616103
City
Wrocław
ZIP/Postal Code
52-416
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616108
City
Wrocław
ZIP/Postal Code
54-144
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616110
City
Łódź
ZIP/Postal Code
90-752
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616105
City
Łódź
ZIP/Postal Code
91-034
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 616101
City
Łódź
ZIP/Postal Code
91-495
Country
Poland
Individual Site Status
Recruiting
Facility Name
Local Site # 703103
City
Bratislava
ZIP/Postal Code
811 09
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Locla Site # 703101
City
Košice
ZIP/Postal Code
040 13
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Local Site # 703104
City
Prešov
ZIP/Postal Code
080 01
Country
Slovakia
Individual Site Status
Recruiting
Facility Name
Local Site # 703102
City
Šahy
ZIP/Postal Code
936 01
Country
Slovakia
Individual Site Status
Recruiting

12. IPD Sharing Statement

Plan to Share IPD
Undecided

Learn more about this trial

VTX958 for the Treatment of Moderately to Severely Active Crohn's Disease

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