Opium Tincture Against Chronic Diarrhea - Patients
Chronic Diarrhea
About this trial
This is an interventional treatment trial for Chronic Diarrhea focused on measuring Diarrhea, Gastrointestinal transit
Eligibility Criteria
Inclusion Criteria: • Signed informed consent before any study specific procedures Able to read and understand Danish Male or female with an age of 20 years or more The researcher believes that the participant understands what the study entails, are capable of following instructions, can attend when needed, and are expected to complete the study. The investigator will ensure that fertile female participants have a negative pregnancy test before each treatment visit and use contraception during the entity of the study. Specific underlying pathophysiology has been identified, but targeted treatment (e.g. antibiotics or bile acid sequestrants) and treatment with loperamide has failed. OR No specific underlying pathophysiology has been identified and treatment with loperamide has failed. At least 6 months post-surgery in the gastrointestinal tract No sign of cancer at standard clinical follow-up Chronic diarrhea defined as at least 3 daily bowel movements for the last week Exclusion Criteria: • Known allergy towards pharmaceutical compounds similar to Dropizol. Participation in other studies within 14 days of first visit (1 year if opioids involved). Expected need of medical/surgical treatment during the study History of psychiatric illness (e.g. mental retardation, schizophrenia, major depression) History of substance abuse (e.g. alcohol, THC, benzodiazepine, central stimulants and/or opioids) Family history of substance abuse Known major stenosis of the intestines Known severe decreased renal function (defined as eGFR below 30) Known severe decreased hepatic function (defined as Child-Pugh class B or higher) Treatment with MAO- inhibitors during the entity of the study Severe COPD or acute severe asthma (defined as FEV1 below 50 % or acute ongoing exacerbation) Known cor pulmonale Female participants that are lactating Medicine known to affect gastrointestinal motility must not be initiated during the entity of the study Treatment with opium tincture during the last month
Sites / Locations
- Aalborg University HospitalRecruiting
- Aarhus University hospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Active treatment
Placebo treatment
Administration of opium tincture (Dropizol)
Administration of placebo (identical to opium tincture in taste and appearance)