A Trial of HRS8179 on Brain Swelling After Large Hemispheric Infarction

Inclusion Criteria: Fully understand and voluntarily participate in this research, and sign the informed consent form (the informed consent form can be signed voluntarily by the person or legal representative); Aged 18~80, regardless of gender; A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA) territory; NIHSS ≥ 10 points at screening; A large hemispheric infarction is defined as: lesion volume of 80 to 300 cm3 on magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computed tomography perfusion (CTP). The study drug initiated must be no later than 10 hours when stroke onset; Exclusion Criteria: The investigator judges that the subject may withdrawn the supportive treatment on the first day; The investigator believes that there is evidence indicating a concurrent infarction in the contralateral hemisphere sufficiently serious to affect functional outcome.3. There are clinical signs of brain hernia; CT/MRI suggested that the anterior septal/pineal excursion was >2 mm due to brain edema; CT/MRI indicates cerebral hemorrhage (excluding small ecchymosis/punctate hemorrhage);