Effect of Esmolol on Perioperative Stress Reaction
Esmolol, Stress Reaction, Airway Obstruction
About this trial
This is an interventional treatment trial for Esmolol focused on measuring continuous infusion
Eligibility Criteria
Inclusion criteria American Society of Anesthesiologists (ASA) Physical Status I to III.; Body mass index (BMI): 20-30 kg/m2; Elective airway intervention under general anesthesia with jet ventilation,duration of operation less than 2hs; Sign informed consent for clinical trial Exclusion criteria The patient and his or her family refused to participate in the study; Severe respiratory or/cardiovascular or/ neurological disease, or/ hepatic or/renal dysfunction Those who are allergic to the drugs used in this study; Psychiatric history or with unstable mental state; Patients with atrioventricular block Patients with history of asthma Patients now treated with β-adrenergic receptor blockers Patients participating in other clinical trial
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
esmolol group
Saline solution
esmolol group: esmolol 50 μg/kg /min were intravenously administered before Operation beginning. If HR(heart rate)is greater than 90 beats/min, esmolol 50μg/kg /min is added each time, with interval more than 5 min and the peak value is 200 μg/kg/min. If the heart rate is lower than 60 times/minute, Stop medication.
Saline group: saline 50 μg/kg /min were intravenously administered before Operation beginning. If HR(heart rate)is greater than 90 beats/min, saline 50μg/kg /min is added each time, with interval more than 5 min and the peak value is 200 μg/kg/min. If the heart rate is lower than 60 times/minute, Stop medication.