Janus Kinase Inhibition in Sarcoidosis

Inclusion Criteria: Written informed consent. Male and female patients age 18 years old or older. Diagnosis of moderate to severe cutaneous sarcoidosis (CSAMI of 10 or greater) with supportive skin biopsy in which other causes of granulomas (infectious, foreign body) have been ruled out. Patients with either: Cutaneous Sarcoidosis Activity and Morphology (CSAMI) activity score greater than or equal to 10 (patients with a CSAMI greater than or equal to 10 have active cutaneous sarcoidosis involving several distinct cutaneous sites, have moderate to severe disease and would otherwise be considered candidates for systemic therapy), or any CSAMI score and skin involvement causing functional impairment (i.e. nasal or visual field obstruction) If patients are taking other systemic therapies for their sarcoidosis, they must be taking a stable dose of the other medication(s) for at least 3 months with no plans to change the regimen in the next 6 months. With the exception of methotrexate or low dose prednisone (20 mg or less per day), use of concomitant immunosuppressants, e.g. infliximab, azathioprine, etc., will not be permitted. Washout of topical medications will be for 2 weeks. Washout for oral medications will not be possible in most cases. Patients will be allowed to continue concomitant prednisone (up to 20 mg daily) or weekly methotrexate (up to 15 mg daily). Females of childbearing potential must agree to use birth control during the study and there must be a negative pregnancy test documented prior to starting the medication. Patients must be willing to have skin biopsies, blood collection, and total body photography and to comply with clinic visits. Exclusion Criteria: Age <18 years old. Patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin). a) Cutaneous Sarcoidosis Activity and Morphology (CSAMI) activity score less than or equal to 10 or Patients known to be HIV or hepatitis B or C positive, or have an active, serious infection herpes simplex, herpes zoster, and pneumonia. This would also include localized infections as per what is reflected in their medical records. Patients diagnosed with Rheumatoid Arthritis (RA). Patients with positive tuberculin skin test or positive QuantiFERON TB test. Patients with significant hepatic impairment (i.e., Child Pugh C). Patients with moderate to severe renal impairment. Patients with uncontrolled peptic ulcer disease. Patients with advanced or untreated malignancy with the exception of treated non-melanoma skin cancer. Patients with a history of deep vein thrombosis and/or pulmonary embolism and/or clotting disorder. Patients taking immunosuppressive medications, with the exception of methotrexate (up to 20 mg weekly allowed) and/or low-dose prednisone (up to 20 mg daily allowed), including but not limited to mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or TNF-α inhibitors. Women of childbearing potential who are unable or unwilling to use birth control while taking the medication. Women who are pregnant or nursing. Current smoker or history of any tobacco use. Screening labs outside the normal range for parameters associated with potential risk for treatment under investigation. Including but not limited to: Platelets <150,000/mm3 Absolute neutrophil count <1,000/mm3 Hemoglobin levels <8 g/dL Absolute Lymphocyte Count <300/mm3 Patients with any medical, psychiatric or social condition that is likely to unfavorably affect the risk-benefit of continued study participation, interfere with study compliance or confound safety or efficacy assessments. Patients who are taking moderate to strong inhibitors of both CYP2C19 and CYP2C9, or strong CYP2C19 or CYP2C9 inducers, as well as P-gp substrate where small concentration changes may lead to serious or life-threatening toxicities. Patients who have recently received a live vaccine. Patients should wait a minimum of 2 weeks, if recently vaccinated, prior to initiating treatment and should not receive a live vaccine during treatment or 2 weeks post-treatment.