The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
Infertility, Female
About this trial
This is an interventional treatment trial for Infertility, Female focused on measuring Erzhi Tiangui Formula, Poor ovarian response, In Vitro Fertilization and Embryo Transfer (IVF-ET), Advanced maternal age
Eligibility Criteria
Inclusion Criteria: Women under 42 years of age with a poor ovarian response (according to the Bologna criteria) . Exclusion Criteria: Individuals with a Body Mass Index (BMI) ≥ 35 Kg/m2. Those with a history of unilateral oophorectomy or recurrent pregnancy loss, defined as two or more spontaneous abortions. Acceptors of donated oocytes or performed either In vitro Maturation (IVM) or blastocyst biopsy for Preimplantation Genetic Diagnosis (PGD) or Preimplantation Genetic Testing for Aneuploidies (PGT-A). Those previously diagnosed with congenital (e.g., mediastinal uterus and double uterus) or acquired (e.g., submucosal myoma and adenomyosis) uterine abnormalities. Presence of a non-surgically treated hydrosalpinx or endometrial polyp and an ovarian endometriosis cyst requiring surgery, during ovarian stimulation. Allergy to or intolerance of the drugs used in the study. Combined contraindications to assisted reproductive technology or pregnancy, such as uncontrolled abnormalities of liver and kidney function, diabetes mellitus (glycosylated haemoglobin ≤7%, fasting blood glucose <10 mmol/L ), hypertension, thyroid disease, symptomatic heart disease, moderate to severe anaemia, history of malignancy or thromboembolism or propensity to thrombosis, severe psychiatric disorder, acute infections of the genitourinary system, sexually transmitted diseases, serious adverse habits such as drug abuse, exposure to teratogenic amounts of radiation, toxins, or drugs (such as prednisone or other hormones, adrenaline, antibiotics, or hypertension, cardiovascular, or antiviral medications) during the active procedure period , and uterine factor infertility or physical illness which prevents the ability to bear a pregnancy.
Sites / Locations
- The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
EZTG group
Control group