Surgical Treatment of Peri-implantitis Using a Bone Substitute With or Without a Resorbable Collagen Membrane
Peri-Implantitis, Surgery
About this trial
This is an interventional treatment trial for Peri-Implantitis focused on measuring peri-implantitis, bone augmentation, collagen membrane, surgical treatment, dental implant
Eligibility Criteria
Inclusion Criteria: To be enrolled, the participant must meet the following inclusion criteria: age 18 years or older be patients of record at the University of Pittsburgh Periodontics Department Systemically healthy patients Full-mouth plaque score and full-mouth bleeding score ≤ 30% (measured at six sites per tooth) Study individuals will be included if they met the following criteria: (a) one or more peri-implant sites with PPD ≥6 mm combined with BOP/suppuration, and (b) peri-implant marginal bone loss, defined as a crater like defect ≥3 mm as assessed from intra- oral radiographs, (c) Infrabony circumferential defect of more than 270° determined by CBCT, (d) crown not possible to retrieve before surgery Exclusion Criteria:study individuals will be excluded if any of the folllowing apply: Unlikely to be able to comply with study procedures and unable to return to SDM for multiple appointments over the course of about a year. Uncontrolled pathologic processes in the oral cavity (cancer and active periodontal disease) History of allergic reactions to dental local anesthetics History of head and neck chemotherapy or radiation within 5 years prior to surgery Systemic or local disease or condition that could compromise post-operative healing and/or osseointegration, such as HIV infection, Paget's disease, osteoporosis, etc. Reported diagnosis of diabetes mellitus Patients taking corticosteroids, IV bisphosphonates, or any immunosuppressant medication that could influence post-operative healing and/or osseointegration Smokes more than 10 cigarettes/day (self-reported) History or current medications with known side effects of gingival growth (including any of the following: phenytoin, phenobarbital, lamotrigine, vigabatrin, ethosuximide, topiramate, primidone, nifedipine, diltazem, amlodipine, felodipine, verapamil, cyclosporine). Present alcohol and/or drug abuser (self-reported) Pregnant, unsure pregnancy status, or lactating females (self-reported), or planning to become pregnant within 1 year of study enrollment
Sites / Locations
- University of Pittsburgh School of Dental Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Bone grafting with collagen membrane
Bone grafting without collagen membrane
This arm will receive surgical intervention involving placement of a bone xenograft subsitute (InterOss Collagen) into the peri-implant bone defect with a collagen membrane (InterCollagen Guide) placed over the bone graft.
This arm will receive surgical intervention involving placement of a bone xenograft subsitute (InterOss Collagen) into the peri-implant bone defect with no collagen membrane placed over the graft.