The Effect of Esmolol Versus Dexmedetomidine on Postoperative Pain Control in Endoscopic Sinus Surgery: A Randomized Trial
Patient's Satisfaction, Depth of Anesthesia
About this trial
This is an interventional treatment trial for Patient's Satisfaction focused on measuring postoperative pain, emergence of aneasthesia
Eligibility Criteria
Inclusion Criteria: 70 patients with American Society of Anesthesiologists (ASA) Physical Status Class I&II, aged > 18 years. and scheduled for FESS. Exclusion Criteria: 1. The patients on β-blockers and cardiovascular active drugs 2. History of neuromuscular disorder, diabetic neuropathy, pregnancy 3. Prolonged QT interval and ventricular arrhythmia, specifically a pre-disposition to bradycardia or conduction abnormalities, cyanotic cardiac disease, and use of medications that would increase the risk of bradycardia. 4. Current (Within the last 30 days) opioid use for pain control as sickle cell disease, substance abuse or benzodiazepine addiction 5. History of end stage hepatic, renal, diabetes mellitus, and bleeding disorders, 6. Allergy and hypersensitivity to the drugs used in the study 7. Excessive use of analgesics/non-steroidal anti-inflammatory drugs 8. Morbid obesity (body mass index (BMI) > 40) 9. A positive history of motion sickness, women who had a history of nausea and vomiting before menstruation.
Sites / Locations
- Faculty of Medicine, Tantan University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
dexmedetomidine group
Esmolol group
35 patients will be received dexmedetomidine (Precedex; Abbott Laboratories, North Chicago, Illinois, USA) (vial = 2 ml) 100 mcg/ml at bolus dose of 1 mcg /kg slowly infused over 10 min, then continuous infusion by a rate of 0. 5 mcg /kg/h., infused by a syringe pump. infusion stopped immediately upon extubation.
35 patients will be received i.v. received a loading dose of esmolol 0.5 mg/kg in 30 mL isotonic saline in the IV line, followed by an IV infusion of esmolol 0.05 mg/kg/min. infusion stopped immediately upon extubation.