Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE) (CLODETTE)
Venous Thromboses, Thromboembolic Disease, Neutrophil Extracellular Trap Formation
About this trial
This is an interventional diagnostic trial for Venous Thromboses focused on measuring Thrombosis, Venous thrombosis, Clonal hematopoiesis of indetermined potential
Eligibility Criteria
Inclusion Criteria: Patients (male or female) less than 50 y.o with : Splanchnic venous territory thrombosis or Cerebral venous thrombosis or Venous thrombosis of the upper limb or Pulmonary embolism (1st episode if male, 2nd episode if female) unprovoked or 1 episode of deep vein thrombosis + 1 episode of arterial thrombosis Exclusion Criteria: Presence of a major or minor transient venous thrombosis risk factor: Surgery within the last 3 months preceding the qualifying thrombotic episode Lower limb fracture with immobilization > 3 days in the last 3 months preceding the qualifying thrombotic episode Presence of estro-progestational contraception Pregnancy Immobilization for acute medical reasons within the last 3 months preceding the qualifying thrombotic episode Air or car travel > 6 hours Presence of a major or minor persistent risk factor for venous thrombosis: Presence of active cancer (solid cancer or hematologic malignancy) Chronic inflammatory digestive or joint diseases Ongoing treatment with heparin (low molecular weight heparin (LMWH) or unfractionated heparin (UFH)) Presence of an abnormality on the thrombophilia test among the following abnormalities Protein C deficiency Protein S deficiency Anti-thrombin deficiency Heterozygous or homozygous factor II mutation Heterozygous or homozygous factor V mutation Presence of anti-phospholipid syndrome Presence of myeloproliferative neoplasia Presence of paroxysmal nocturnal hemoglobinuria
Sites / Locations
- CHU de Bordeaux, Service de Neurologie
- CHU de Bordeaux, Service Gastro-Entérologie
- CHU de Bordeaux, Service Hématologie BiologiqueRecruiting
- CHU de Bordeaux, Service Médecine Vasculaire
- CHU de Bordeaux, Unité ambulatoire de Médecine VasculaireRecruiting