Bicyclol in the Treatment of Antineoplastic Drug-induced Liver Injury.

A Prospective and Multicenter Cohort Study of Bicyclol in the Treatment of Antineoplastic Drug-induced Liver Injury.

The clinical trial is designed to evaluate the efficacy of bicyclol for patients with antineoplastic drug-induced liver injury and investigate factors effecting the therapeutic outcome.

This study prospectively studied the treatment of acute drug-induced liver injury related to anti-tumor with bicyclol tablets, to provide medical evidence in clinical practice of bicyclol treating acute drug-induced liver injury. The main purpose of this study is to evaluate the clinical efficacy and outcome of bicyclol tablets in the treatment of drug-induced liver injury and analyze the bicyclol tablet's therapeutic effects in different groups including conventional chemotherapy drugs, targeted drugs, and immunosuppressants. The secondary purpose of this study is to analyze the factors influencing the prognosis and outcome of bicyclol tablets in the treatment of acute DILI.

Excellence: clinical symptoms and signs disappeared, serum ALT returned to normal; Improvement: clinical symptoms disappeared (improved), serum ALT decreased more than 50% of the original value; Invalid: Failure to meet the above criteria

Inclusion Criteria: The acute liver injury caused by anti-tumor drugs The RUCAM assessment scale ≥6 The liver injury must in the acute phase Must be treated with bicyclol tablets Must sign informed consent - Exclusion Criteria: This acute liver injury caused by non-anti-tumor drugs Pregnant women Lactating women Childbearing age women are plan to conceive

Based on the principle of confidentiality of subjects' privacy and related information, this plan not to make IPD available to other researchers.

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