The Effects of Ferric Derisomaltose on Postoperative Anemia in Spinal Deformity Surgery
Perioperative Anemia, Surgery, Spinal Deformity
About this trial
This is an interventional treatment trial for Perioperative Anemia focused on measuring spinal deformity surgery, perioperative anemia, ferric derisomaltose, adult
Eligibility Criteria
Inclusion Criteria Age ≥18 years Received spinal deformity surgery 70 g/L ≤ Hb ≤ 110 g/L at POD1, or Hb ≤120 g/L at POD1 with a decrease in Hb of ≥20 g/L compared with baseline Informed consent was obtained voluntarily Exclusion Criteria Women who are pregnant, breastfeeding, or planning to become pregnant. known serious hypersensitivity to other parenteral iron products Non-iron deficiency anemia (e.g., hemolytic anemia) Decompensated liver insufficiency Coexisting active infection Drug abuse, including but not limited to opioids, amphetamines, methamphetamine, ketamine, etc. Other conditions that the investigator considers inappropriate for participation (e.g. deafness, Parkinson's disease, communication disorders, etc.) Participation in another clinical trial within three months prior to this study.
Sites / Locations
- Peking Union Medical College HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Treatment group
Control group
Iron to be administered as intravenous ferric derisomaltose: Where Hb (hemoglobin) ≥100 g/L, dosage according to body weight is as follows: Body weight <50 kg: 500mg; Body weight 50 to <70 kg: 1000 mg; Body weight ≥70 kg: 1500 mg. Where Hb <100 g/L, dosage according to body weight is as follows: Body weight <50 kg: 500mg; Body weight 50 to <70 kg: 1500mg; Body weight ≥70 kg: 2000 mg. The maximial dose should not exceed 20mg/kg body weight, rounded off to the nearest 100mg
Iron to be administered as oral ferrous succinate: 1 tablet (100 mg) tid (three times daily), starting on the first postoperative day and continuing for 4 weeks.