Comparison of Pallidal With Subthalamic Deep Brain Stimulation for Cervical Dystonia
Cervical Dystonia
About this trial
This is an interventional treatment trial for Cervical Dystonia focused on measuring globus pallidus internus, subthalamic nucleus, deep brain stimulation
Eligibility Criteria
Inclusion criteria Diagnosed as idiopathic or hereditary isolated CD; Severe functional impairment; Oral medication and injection of botulinum toxin become ineffective (> 3 months since last injection), or refuse to adopt botulinum toxin injection; No secondary causes of CD; Age 18-80 years old; Normal neurological examination except for dystonia; Normal brain MRI; The subject or their family members can fully understand the trial and sign the informed consent; Good compliance and willingness to receive regular follow-ups. Exclusion criteria Diagnosed as secondary CD; CD with obvious trunk/limb involvement, or Meige syndrome; History of severe mental disorders, dementia, or epilepsy; Previous dystonia surgery (pallidotomy, thalamotomy, DBS, etc); Accompanied by other neurological diseases (Parkinson's disease, essential tremor, multiple sclerosis, stroke, etc); The patient has or needs other implantable devices (cardiac pacemakers, defibrillators, cochlear implants, spinal cord stimulators, etc); Pregnant women or women who are waiting to become pregnant during the trial; Poor health condition.
Sites / Locations
- Chinese PLA General Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
GPi-DBS
STN-DBS
The DBS electrodes are implanted into posteroventral GPi bilaterally.
The DBS electrodes are implanted into dorsolateral STN bilaterally.