The OPTIMISE Study
Pseudophakic Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Intraocular Pressure
About this trial
This is an interventional treatment trial for Pseudophakic Bullous Keratopathy focused on measuring Descemet Stripping Endothelial Keratoplasty, Cornea
Eligibility Criteria
Inclusion Criteria: - Patients aged 21 years or older registered on the NOTR as candidates for DMEK corneal transplantation Exclusion Criteria: Inability to complete follow up or comply with study procedures Previous corneal graft in the study eye Known sensitivity or contraindication to the ingredients in the study medications History of uveitis or herpetic keratitis Human Leukocyte Antigen (HLA) typed allograft Pregnancy (current and planned) or lactation Use of other local or systemic immunosuppressive drugs
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Experimental
Active Comparator
Intervention STEP I (Year 1 after DMEK)
Control STEP I (Year 1 after DMEK)
Intervention STEP II (Year 2 after DMEK)
Control STEP II (Year 2 after DMEK)