Changes in Lung Aeration and Inspiratory Effort With and Without Awake Prone
Respiratory Distress Syndrome, Ventilation Therapy; Complications
About this trial
This is an interventional treatment trial for Respiratory Distress Syndrome
Eligibility Criteria
Inclusion Criteria: adult patients (18-90 years) who have acute hypoxemic respiratory failure, requiring FIO2 > 0.4 to maintain SpO2 at 90-95% during HFNC at 50 L/min Exclusion Criteria: patients who need immediate intubation; refuse to participate in the study; unable to communicate; have contraindication to place the esophageal catheter; unable to use EIT, such as open-chest surgery with chest tube placement; have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure.
Sites / Locations
- Zhongshan hospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Placebo Comparator
Placebo Comparator
HFNC SP
HFNC PP
NIV SP
NIV PP
MC SP
MC PP
HFNC flow at 60 L/min or maximum tolerable flow at supine position
HFNC flow at 60 L/min or maximum tolerable flow at prone position
CPAP with full face mask at 10 cmH2O at supine position
CPAP with full face mask at 10 cmH2O at prone position
Mask oxygen at supine position
Mask oxygen at prone position