The Efficacy and Cerebral Mechanism of Intradermal Acupuncture for Major Depressive Disorder
Major Depressive Disorder
About this trial
This is an interventional treatment trial for Major Depressive Disorder focused on measuring Major Depressive Disorder, Intradermal Acupuncture, Magnetic Resonance Imaging
Eligibility Criteria
Inclusion Criteria: Patients diagnosed with MDD according to the International Classification of Disease-10 (ICD-10); Aged between 18 and 60 years (no limitation on gender); Administration of SSRIs; Patients undergoing MRI and MRS should be right-handed and free of traumatic brain injury, claustrophobia or metal implants; Written informed consent is obtained by the person or guardian. Exclusion Criteria: ICD-10 diagnoses: schizophrenia, bipolar disorder, manic episode or other psychotic disorders; alcohol and drug addiction; Significant skin lesions, severe allergic diseases, tumors, and severe or unstable internal diseases involving the cardiovascular, digestive, endocrine, or hematological system; Acute suicidal tendency; Allergy to adhesive tape and fear of intradermal acupuncture; Pregnancy and lactation; Mental retardation and difficulty cooperating with doctors. Participating in other clinical trials.
Sites / Locations
- the Third affiliated hospital of Zhejiang Chinese Medical university [Recruiting]Recruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Sham Comparator
Experimental
Waiting list group
SIA group
AIA group
This group will include 40 patients with MDD who will be treated with oral SSRIs only, the dosage of which will be determined by the psychiatrist. At the end of this trial, patients could choose 6 weeks' intradermal acupuncture treatments free of charge.
This group will include 40 patients with MDD who will be treated with sham intradermal acupuncture (SIA) combined with SSRIs. Acupoints related to MDD will be stimulated by acupuncturists and the dosage of oral SSRIs will be determined by the psychiatrist.
This group will include 40 patients with MDD who will be treated with active intradermal acupuncture (AIA) combined with SSRIs. Acupoints related to MDD will be stimulated by acupuncturists and the dosage of oral SSRIs will be determined by the psychiatrist.