A Feasibility Trial of OCM Supplements for the Treatment of NAFLD
NAFLD
About this trial
This is an interventional treatment trial for NAFLD
Eligibility Criteria
We will enroll NAFLD patients, blocked by age 50 years (≤ 50; > 50) and sex (M; F, four patients/subjects in each block). Inclusion Criteria for NAFLD Group: Increased hepatic fat accumulation diagnosed by either abdominal ultrasound or CT AND elevated CAP score of 280 dB/m or higher HOMA-IR ≥ 2 or the diagnosis of metabolic syndrome Chronic elevation of transaminases: ALT elevation (more than 2 times during the past 12 months, defined by 19 U/L for women and 30 U/L for men 31) Stable use of any potential anti-NASH therapy (i.e., vitamin E, pioglitazone, glucagon like peptide 1 agonist, etc.) for 6 months prior to screening. Aged 18+ years Able to provide legal consent Exclusion Criteria for NAFLD Group: Any contraindication to the study supplements Inability to obtain valid fibroscan measures at the screening Pregnancy or lactation Clinical diagnosis of cirrhosis or other chronic liver diseases Recent use of steatogenic medications Excess alcohol use (>21/ >14 drinks weekly in men/women) Chronic kidney disease Supplement use within 30 days, containing any of the study supplements Total parenteral nutrition Any clinical conditions associated with malabsorption Any active diagnosis of malignancy Use of immunosuppression
Sites / Locations
- Duke UniversityRecruiting
Arms of the Study
Arm 1
Experimental
NAFLD Group
The NAFLD group will be asked to take Hcy lowering supplements (Vitamin B12, Folate, Vitamin B6, and Betaine) daily for 12 weeks. Over the course of approximately 12 to 13 weeks, participants will complete two in person visits and two phone visits. During the in person visits NAFLD participants will complete the following activities: Review medical history; Physical examination; Vital signs (blood pressure, heart rate, respiratory rate, body temperature); Measure height, weight, body mass index, and waist circumference; Grip test; Fasting blood tests; Pregnancy test (if applicable); Fibroscan with CAP score; QOL questionnaire