PRO1160 for Advanced Solid and Liquid Tumors (PRO1160-001)
Renal Cell Carcinoma, Nasopharyngeal Carcinoma, Non Hodgkin Lymphoma
About this trial
This is an interventional treatment trial for Renal Cell Carcinoma
Eligibility Criteria
Inclusion Criteria: Pathologically confirmed metastatic or unresectable solid malignancy including Renal Cell carcinoma, Nasopharyngeal carcinoma or Stage III or IV Non Hodgkin Lymphoma Relapsed or refractory disease following prior systemic therapies known to confer medical benefit Willing to provide a tumor sample (archive tissue or fresh biopsy) ECOG performance status 0 or 1 Measurable disease per RECIST v1.1 for RCC and NPC and per Lugano for NHL Exclusion Criteria: Prior treatment with anti-CD70 directed therapy Other malignancy within 3 years Active CNS metastases (treated, stable CNS metastases are allowed) Uncontrolled Grade 3 or greater infection within 2 weeks Positive for HBV, HCV or HIV Use of a strong P450 CYP3A inhibitor within 14 days (dose escalation only) Additional protocol defined inclusion/exclusion criteria may apply
Sites / Locations
- City of HopeRecruiting
- City of Hope- LennarRecruiting
- University of Michigan
- Karmanos Cancer Institute
- Washington UniversityRecruiting
- Albert Einstein Montefiore
- NYU Lagone Health
- Levine Cancer InstituteRecruiting
- Cleveland ClinicRecruiting
- Providence Cancer InstituteRecruiting
- OHSU
- Sarah Canon Research InstituteRecruiting
- The University of Texas-MD Anderson Cncer Center
- START Mountain RegionRecruiting
- Cancer Hospital Chinese Academy of Medical Science
- Affiliated Cancer Hospital and Institute of Guangzhou Medical University
- Sun Yat-sen University Cancer Prevention Center
- Fudan University Shanghai Cancer CenterRecruiting
- Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Arms of the Study
Arm 1
Experimental
PRO1160
PRO1160 monotherapy in escalating doses in Part A and at the recommended phase 2 dose in Part B