Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial (CARES)
Surgery, Pain, Postoperative
About this trial
This is an interventional treatment trial for Surgery focused on measuring Medications after surgery, NSAIDS, Acetaminophen, Opioids, laparoscopic gallbladder removal, inguinal hernia repair, breast lumpectomy, Analgesics, non-narcotic
Eligibility Criteria
Inclusion Criteria: No significant analgesic medication use before surgery: For this study, significant analgesic medication use before surgery as use of prescriptions for opioid or NSAID medications in the past 30 days, or over-the-counter NSAID use on greater than 7 of 30 past days, as reported by the patient. One of three common low-risk surgical procedures: For this study, the three-common low-risk surgical procedures will include laparoscopic gallbladder removal, inguinal hernia repair, and breast lumpectomy. Exclusion Criteria: Anticipated other surgery within 6 months or anticipated life expectancy of less than 6 months Patients with contraindications to NSAID drugs in the NSAID arm, opioid drugs in the OPIOID arm, or acetaminophen will be excluded. There are specific contraindications that will be reviewed per protocol.
Sites / Locations
- University of MichiganRecruiting
- Henry Ford Health System
- Washington University in Saint Louis
- Unity Health Toronto
Arms of the Study
Arm 1
Arm 2
Other
Other
NSAID regimen
Opioid regimen
Surgical teams will elect for one of the medications within the treatment arm to which the patient is randomized.