The Metabolic Effects of Intermittent Fasting
Normal and Overweight Individuals at High-risk of Diabetes
About this trial
This is an interventional prevention trial for Normal and Overweight Individuals at High-risk of Diabetes
Eligibility Criteria
Inclusion Criteria: Men and women, ages 25-45 years BMI of at least 21 kg/m2 and up to and including BMI of 29 kg/m2 Normal thyroid function Regular menses (women) At least one first-degree relative with type 2 diabetes (T2D) and/or history of gestational diabetes Exclusion Criteria: Any chronic diseases including hypertension and Type 2 diabetes mellitus Indication for lipid-lowering therapy in non-diabetics, using the more stringent AHA guideline cutoff (LDL>190 or an estimated 10-year ASCVD risk of >7.5%) Chronic medications, including oral contraceptive pills Pregnant and/or breastfeeding History of an eating disorder 25-OH vitamin D level < 20 ng/mL Active substance abuse, including alcohol Subjects with a prior history of intermittent fasting The study physician feels that the subject may not be able to safely complete the protocol or may place themselves at risk by undergoing the protocol
Sites / Locations
- University of PittsburghRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
Fasting
Fasting with weight maintenance
Counseling
Subjects will fast one-day per week for 12 weeks
Subjects will fast one-day per week for 12 weeks and maintain body weight
Subjects will be counseled on optimal diet and activity recommendations to maintain/achieve a normal BMI (standard of care)