Effects of Peanut Consumption on Brain Function
Brain Vascular Function, Cerebral Blood Flow, Brain Insulin Sensitivity
About this trial
This is an interventional prevention trial for Brain Vascular Function
Eligibility Criteria
Inclusion Criteria: Men and women, aged between 60-75 years BMI between 20-35 kg/m2 Fasting plasma glucose < 7.0 mmol/L Fasting serum total cholesterol < 8.0 mmol/L Fasting serum triacylglycerol < 4.5 mmol/L Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg Stable body weight (weight gain or loss < 3 kg in the past three months) Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study No difficult venipuncture as evidenced during the screening visit Exclusion Criteria: Allergy or intolerance to peanuts Left-handedness Current smoker, or smoking cessation < 12 months Diabetic patients Familial hypercholesterolemia Abuse of drugs More than 3 alcoholic consumptions per day Use of products or dietary supplements known to interfere with the main outcomes as judged by the principal investigators Use medication to treat blood pressure, lipid, or glucose metabolism Use of an investigational product within another biomedical intervention trial within the previous 1-month Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases, and rheumatoid arthritis Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident Contra-indications for MRI imaging (e.g., pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)
Sites / Locations
- Maastricht University Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Experimental
Control
Skin roasted peanuts
No skin roasted peanuts