Supportive Treatment and Antibiotics for Mild Pediatric Pneumonia (STAMPP)

Inclusion Criteria: Age 12-71 months; and Diagnosis of CAP, defined using established criteria: Signs and symptoms of lower respiratory tract infection (LRTI), defined as any of the following: new or different cough; or new or different sputum production; or chest pain; or dyspnea/shortness of breath; or documented tachypnea; or abnormal findings consistent with LRTI on physical examination (e.g., crackles/rales, rhonchi, wheezing) and Fever, defined as tactile temperature at home or measured temperature ≥38ºC rectal, ≥37.7ºC oral, or ≥37.5ºC axillary, and Clinician diagnosis of CAP, Intention to treat as an outpatient after ED/primary care visit, and Mild disease, defined as lack of respiratory distress per adapted Pediatric Infectious Diseases Society/Infectious Diseases Society of America criteria: none of the following: dyspnea, concerning retractions per treating clinician, grunting, nasal flaring, apnea, altered mental status, SpO2<93% in room air, or respiratory rate >50 breaths per minute for ages 12-24 months or respiratory rate > 40 breaths per minute if age>24 months. Exclusion Criteria: Hospitalization within one-month preceding study visit; or Incomplete immunization status (<2 doses of Hib and pneumococcal vaccines); or Chronic complex medical conditions (chronic heart disease followed by cardiology, chronic lung disease (not including asthma), congenital airway or lung malformations, cystic fibrosis, tracheostomy tube, requiring positive-pressure ventilation, neuromuscular disorders affecting the lungs or chest wall); or Conditions that compromise the immune system (HIV with CD4 count less than 400, primary immunodeficiency, asplenia, sickle cell disease, receipt of hematopoietic stem cell or solid organ transplant, cancer on active chemotherapy, immunosuppressive agents, daily corticosteroids for more than 7 consecutive days in past 14 days); or Systemic antibiotic receipt (more than 1 dose) within the previous two weeks of CAP diagnosis; or Radiographic findings of a consolidation of a concerning size or complexity in the view of the treating clinician; or Radiographic findings of complicated pneumonia (pleural effusion larger than trace in size, empyema, [complex/septated collection] abscess, necrotic lung disease); or Pneumonia known to be due to bacterial source at the time of enrollment, as documented by blood culture or PCR if available, or another clear source of bacterial infection requiring immediate antibiotics; or Diagnosed with pneumonia in the previous month; or Provider diagnosis of aspiration pneumonia; or Severe (type 1) drug allergy to amoxicillin; or Any other condition that in the judgement of investigators or the clinical team could affect safety of the subject; or No access to a telephone or video technology for follow-up; or Current enrollment in another clinical trial of an investigational agent; or Previous enrollment in this trial; or Parent/guardian non-English or non-Spanish speaking; or Known allergy to milk and/or red dye.