The Effect of Pituitrin on the Patients With Pulmonary Hypertension Undergoing Cardiac Surgery
Cardiac Surgery, Hypertension, Pulmonary
About this trial
This is an interventional treatment trial for Cardiac Surgery focused on measuring cardiac surgery, Hypertension, Pulmonary, Pituitary Hormones, Posterior, Extracorporeal Circulation
Eligibility Criteria
Inclusion Criteria: age ≥18 years and ≤80 years; scheduled for elective cardiopulmonary bypass heart surgery (adult congenital heart disease surgery, coronary artery bypass grafting, valve replacement, valvuloplasty, heart transplantation and aortic surgery); Patients who had pulmonary hypertension (Mean pulmonary artery pressure at rest ≥ 25mmhg or pulmonary artery systolic pressure (PASP) ≥ 40mmhg as shown by echocardiography); sign informed consent. Exclusion Criteria: use pituitrin or vasopressin before operation; Patients who had acute coronary syndrome; preoperative use of left ventricular assist devices other than intra aortic balloon - pump (IABP); Patients who had liver, thyroid and adrenal diseases, severe lung diseases, diabetes; Patients who had preoperative renal insufficiency (The increase of serum creatinine (SCR) within 48 h ≥ 0.3mg/dl (or ≥ 26.5 μ mol/L); Or it is known or speculated that the increase of SCR in the past 7 days is more than 1.5 times of the basic value; Or 0.5ml/kg urine volume per hour for 6H); Patients who had severe carotid artery stenosis, preoperative stroke, mental disorder and other difficult to communicate and cooperate; Patients who had peripheral vascular disease, allergy to vasopressin or pituitrin, severe hyponatremia (na+ < 130 mmol/l), acute mesenteric ischemia, pregnancy, malignant tumors, required ECMO and underwent emergency surgery or reoperation; Patients who had participated in other clinical studies in recent 3 months.
Sites / Locations
- Qianfoshan Hospital, The First Hospital affiliated of Shandong First Medical University
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
pituitrin group
normal saline group
The specification of posterior pituitary injection is 1ml/6U, diluted with normal saline to 0.5u/ml, and injected by intravenous pump at the rate of 0.04u/ (kg · h).
Intravenous infusion of normal saline at the same dose and speed