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Techniques and Pitfalls of Multi-Slice CT Coronary Angiography

Primary Purpose

Computed Tomography Angiography, Coronary Artery Disease

Status
Recruiting
Phase
Not Applicable
Locations
Egypt
Study Type
Interventional
Intervention
Coronary computed tomography angiography
Sponsored by
Sohag University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Computed Tomography Angiography

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Male and female patients of at least 18 years of age, with suspected symptomatic CAD. Exclusion Criteria: Un cooperative patients. Those who have allergy to iodinated contrast material or contrast-induced nephropathy, Elevated serum creatinine level (1.5 mg/dl) or creatinine clearance >60 ml/min. Atrial fibrillation. Aortic stenosis. Percutaneous coronary intervention within the past 6 months. Intolerance to beta-blockers. Body mass index > 40 Patients with Agatston calcium scores of >400

Sites / Locations

  • Sohag University hospitalsRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Participants

Arm Description

Outcomes

Primary Outcome Measures

Number of techniques
The number of possible techniques used to perform CT coronary angiography
Number of pitfalls
The number of pitfalls that could mimic coronary artery stenosis and lead to non-assessable segments
Number of possible strategies to overcome the pitfalls of the study

Secondary Outcome Measures

Full Information

First Posted
January 18, 2023
Last Updated
February 6, 2023
Sponsor
Sohag University
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1. Study Identification

Unique Protocol Identification Number
NCT05729490
Brief Title
Techniques and Pitfalls of Multi-Slice CT Coronary Angiography
Official Title
Techniques and Pitfalls of Multi-Slice CT Coronary Angiography
Study Type
Interventional

2. Study Status

Record Verification Date
February 2023
Overall Recruitment Status
Recruiting
Study Start Date
January 1, 2023 (Actual)
Primary Completion Date
October 2023 (Anticipated)
Study Completion Date
February 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Sohag University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
The goal of this study is to describe the techniques for coronary multi-slice CT angiography and to illustrate the spectrum of artifacts that can simulate coronary artery stenosis and lead to non-assessable segments using 128- and 160 multi-detector row CT scanners and discuss post-processing pitfalls with each. In addition, to review the normal anatomy and anatomic variants of the coronary arteries and discuss effective strategies for improving the diagnostic accuracy of coronary CT angiography.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Computed Tomography Angiography, Coronary Artery Disease

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
60 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Participants
Arm Type
Experimental
Intervention Type
Radiation
Intervention Name(s)
Coronary computed tomography angiography
Intervention Description
All patients will be subjected to: Two CT scans (coronary calcium scoring and angiography) using 128 or 160-row scanners with a slice thickness of 0.5 mm (Revolution Evo 128, GE Health care, Chicago, Illinois, USA) or (Aquilion 160, Canon Medical Systems, Tochigi, Japan). Calcium scoring will be performed with the use of prospective electrocardiographic gating with 400-ms gantry rotation, 120-kV tube voltage, and 300-mA tube current. For CTA, retrospective electrocardiographic gating will be used, with heart rate adjusted gantry rotations of 350 ms to 500 ms to enable adaptive multisegmented reconstruction. Iopromide (Ultravist 370, Bayer AG, Berlin, Germany) is the intravenous contrast medium that will be used for CTA. Beta-blockers will be given if the resting heart rate is 70 beats/min.
Primary Outcome Measure Information:
Title
Number of techniques
Description
The number of possible techniques used to perform CT coronary angiography
Time Frame
2 months
Title
Number of pitfalls
Description
The number of pitfalls that could mimic coronary artery stenosis and lead to non-assessable segments
Time Frame
3 months
Title
Number of possible strategies to overcome the pitfalls of the study
Time Frame
3 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male and female patients of at least 18 years of age, with suspected symptomatic CAD. Exclusion Criteria: Un cooperative patients. Those who have allergy to iodinated contrast material or contrast-induced nephropathy, Elevated serum creatinine level (1.5 mg/dl) or creatinine clearance >60 ml/min. Atrial fibrillation. Aortic stenosis. Percutaneous coronary intervention within the past 6 months. Intolerance to beta-blockers. Body mass index > 40 Patients with Agatston calcium scores of >400
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Mostafa M Gad, Resident
Phone
01112386670
Email
mostafa.gad.670@gmail.com
First Name & Middle Initial & Last Name or Official Title & Degree
Mohammed Z Ali, Professor
Facility Information:
Facility Name
Sohag University hospitals
City
Sohag
Country
Egypt
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Magdy M Amin, Professor

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
30157094
Citation
Maroules CD, Rajiah P, Bhasin M, Abbara S. Current Evidence in Cardiothoracic Imaging: Growing Evidence for Coronary Computed Tomography Angiography as a First-line Test in Stable Chest Pain. J Thorac Imaging. 2019 Jan;34(1):4-11. doi: 10.1097/RTI.0000000000000357.
Results Reference
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PubMed Identifier
34565701
Citation
Tridandapani S, Banait-Deshmane S, Aziz MU, Bhatti P, Singh SP. Coronary computed tomographic angiography: A review of the techniques, protocols, pitfalls, and radiation dose. J Med Imaging Radiat Sci. 2021 Nov;52(3S):S1-S11. doi: 10.1016/j.jmir.2021.08.014. Epub 2021 Sep 24.
Results Reference
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PubMed Identifier
22253353
Citation
Sun Z, Choo GH, Ng KH. Coronary CT angiography: current status and continuing challenges. Br J Radiol. 2012 May;85(1013):495-510. doi: 10.1259/bjr/15296170. Epub 2012 Jan 17.
Results Reference
background
PubMed Identifier
19304713
Citation
Donnino R, Jacobs JE, Doshi JV, Hecht EM, Kim DC, Babb JS, Srichai MB. Dual-source versus single-source cardiac CT angiography: comparison of diagnostic image quality. AJR Am J Roentgenol. 2009 Apr;192(4):1051-6. doi: 10.2214/AJR.08.1198.
Results Reference
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Techniques and Pitfalls of Multi-Slice CT Coronary Angiography

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