Closed-loop Synchronization Versus Conventional Synchronization (CHESTSIPP)
Acute Respiratory Failure, Pediatric Respiratory Distress Syndrome
About this trial
This is an interventional treatment trial for Acute Respiratory Failure focused on measuring Acute respiratory failure (ARF), Pediatric acute respiratory distress syndrome (PARDS), Closed-loop, synchronization, patient ventilator asynchrony
Eligibility Criteria
Inclusion Criteria: Pediatric patients older than 1 month and younger than18 years of age Hospitalized at the PICU with the intention of treatment with mechanical ventilation at least for the upcoming 3 hours with spontaneous breathing activity Written informed consent signed and dated by the patient or one relative in case that the patient is unable to consent, after full explanation of the study by the investigator and prior to study participation Exclusion Criteria: Formalized ethical decision to withhold or withdraw life support Patient included in another interventional research study under consent Patient already enrolled in the present study in a previous episode of respiratory failure Pregnant woman Patients deemed at high risk for the need of transportation from PICU to another ward, diagnostic unit or any other hospital Hemodynamic instability defined as a need of continuous infusion of epinephrine or norepinephrine > 1 mg/h Not being able to obtain reference waveform
Sites / Locations
- Aydin Obstetric and pediatrics HospitalRecruiting
- Erzurum Regional Research and Training HospitalRecruiting
- Erzurum Regional Research and Training HospitalRecruiting
- Cam Sakura Research and Training HospitalRecruiting
- The Health Sciences University Izmir Behçet Uz Child Health and Diseases Research and Training HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Close-loop synchronization controller
Conventional
One-hour period where the pressure support of spontaneous effort will be automatically titrated based on pressure and flow waveform analysis obtained from the patient during SPONT mode.
One-hour period where the synchronization of pressure support of patient effort during SPONT mode will be manually set.