Cerebellar Involvement in Alcohol Use Disorder (AUD)
Alcohol Use Disorder
About this trial
This is an interventional treatment trial for Alcohol Use Disorder focused on measuring AUD, heavy drinking, hazardous drinking
Eligibility Criteria
Inclusion Criteria: completed at least 8 years of education Exclusion Criteria: Estimated Intelligence Quotient (IQ) < 90 less than 5th grade reading level Left handed Non-native English speaker current drug use disorder other than alcohol (except nicotine and caffeine) and or recent drug use in the last 90 days Positive breath alcohol level at time of MRI scan or discrepancies between alcohol biomarker and self-report that cannot be resolved Exhibiting symptoms of alcohol withdrawal on visit 1 assessment Significant current psychiatric distress and or treatment History of any central nervous system disorder, presence of a seizure disorder, or use of anticonvulsant medication in the past 3 months any serious medical condition detected on assessment or by medical record review; or have liver function tests more than three times normal at screening History of metal implantation that would preclude MRI scanning; or other implants, pumps, pacemakers that would be contraindications for MRI scanning Abnormal MRI scan or history of significant closed head trauma Evidence of dementia For women, pregnancy
Sites / Locations
- Johns Hopkins University School of MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
Cathodal cerebellar transcranial direct current stimulation (ctDCS)
Anodal cerebellar transcranial direct current stimulation (atDCS)
Sham cerebellar transcranial direct current stimulation (stDCS)
For ctDCS, the cathodal (-) electrode will be positioned over the right cerebellum 1 cm below and 3 cm lateral to the inion, and the anodal (+) electrode will be placed on the contralateral supraorbital area (FP2 EEG location).
For atDCS, anode/cathode locations are reversed from those of ctDCS..
For stDCS, the electrodes will be configured randomly as atDCS 50% of the time, and as ctDCS 50% of the time.