The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle
Aging, Metabolism Disorder, Ketonemia
About this trial
This is an interventional basic science trial for Aging
Eligibility Criteria
Inclusion Criteria: Male 20-25 years old (n = 12) OR male 65-85 years old (n = 12) BMI range: 19 to 27 Stable weight (< 5% change over last 6 months) Less than 3 x 60 min of structured exercise per week. Exclusion Criteria: Medication that affect energy metabolism. Non-MR-compatible metals or electric devices in the body. Anaemia or bleeding disorders. Heart, lung or other disease that affects the subjects ability to exercise. Smoking. Drug abuse. Lack of compliance. Known allergy towards local anaesthetics. Any condition that the principal investigator considers unsuitable for the subject's ability to complete the study.
Sites / Locations
- Steno Diabetes Center AarhusRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
First Ketone, then placebo
First placebo, then ketone
Ingestion of ketone monoester D-β-hydroxybutyrate / D 1,3 butanediol monoester on first experimental day and ingestion of a fat placebo drink on the second experimental day.
Ingestion of a fat placebo drink on the first experimental day followed by ingestion of ketone monoester D-β-hydroxybutyrate / D 1,3 butanediol monoester on the second experimental day.