The Effects of Intermittent Hypoxia on Acute Hypoxic Injury
Acute Mountain Sickness
About this trial
This is an interventional prevention trial for Acute Mountain Sickness
Eligibility Criteria
Inclusion Criteria: Informed written consent from the volunteers. Healthy volunteers between ages of 18 and 45 years, body mass index (BMI) of 19.0 and 24.9 kg/m2. Long-term residence at flatland (altitude of <100 m), not having been to an altitude ≥1500 m in 30 days. Resting peripheral oxygen saturation of more than 90%, cerebral oxygen saturation between 58%-82%, heart rate between 60 bpm and 100 bpm, and blood pressure within the normal range (90-130/60-80 mmHg). Exclusion Criteria: History of cardiovascular, cerebrovascular, pulmonary, hepatic, dermatologic, or hematologic diseases. History of substance abuse. The use of medications or medical devices. Pregnancy, hypertension, diabetes mellitus, obesity, sleep apnea and neurological disorders.
Sites / Locations
- Xuanwu Hospital, Capital Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
IH group
Control group
Participants will receive 10 times intermittent hypoxia (oxygen concentration: 13%) intervention before exposure to acute hypoxia environment.
Participants will receive 10 times sham-hypoxia (oxygen concentration: 21%) intervention in 5 days before exposure to acute hypoxia environment.