Computerized Cognitive Training in Patients With Coronary Heart Disease and Mild Cognitive Impairment (COG-T CHD)
Mild Cognitive Impairment, Coronary Heart Disease
About this trial
This is an interventional treatment trial for Mild Cognitive Impairment focused on measuring Cognitive training, Digital therapy
Eligibility Criteria
Inclusion Criteria: Over the age of 50; Completion of more than 6 years of education; Patients with coronary artery disease confirmed by coronary CT angiography or coronary angiography; Chief complaint of cognitive decline within 1 year; The average score of any cognitive domain in processing speed, situational memory, working memory and visual space measured by the Basic Cognitive Ability Test (BCAT) is less than 1 SD compared with the normal population; Agree to be randomized to cognitive function tests and cognitive training and be able to receive follow-up as required. Exclusion Criteria: Previous definite diagnosis of dementia or brief Mental State Examination Scale (MMSE) < 24 points; Cognitive dysfunction caused by cranial trauma, cranial tumor, Parkinson's disease, schizophrenia, Alzheimer's disease, anxiety and depression, and other neuropsychiatric diseases; Deaf and mute or other reasons cannot communicate normally; Binge drinking or taking drugs (antihistamines, antipsychotics) that affect cognitive function; Unable to master the use of cognitive training equipment after two 1-hour training instructions each time; Patients who plan to undergo coronary intervention within 6 months or have undergone coronary intervention within 1 month; Severe liver and kidney function injury or critical condition, poor prognosis, estimated survival of less than 1 month. Patients who had received general anesthesia within 3 months; History of stroke and craniocerebral trauma within 6 months; History of Parkinson's disease, schizophrenia, and epilepsy; Prior neurosurgery or history of cranial tumors; Nuclear magnetic examination contraindications: such as metal implants, claustrophobia, etc.; patients living alone; Patients with atrial fibrillation, structural heart disease, and infective endocarditis.
Sites / Locations
- Beijing Anzhen HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Cognitive digital therapy group
Positive control group
Computer-based cognitive training for 30 minutes at least 5 times a week for 12 weeks; At the end of the 12 weeks, the subjects were randomly divided into two groups. One group continued the training for 12 weeks, at least five times a week for 30 minutes each time, and the other group stopped the training.
Computer-based cognitive training tasks with low or no difficulty variation for 30 minutes at least five times a week for 12 weeks