Blueberries, Inflammation, Motivation, and Physical Activity
Depressive Symptoms
About this trial
This is an interventional other trial for Depressive Symptoms focused on measuring Anthocyanins, Fiber, Aging
Eligibility Criteria
Inclusion Criteria: Men and women aged ≥65 years Self-reporting ≥ 8 hours of sitting per/day (e.g., sedentary behavior) Depressive symptoms (defined as ≥4 and <16 points on the center for epidemiological studies depression-scale) Exclusion Criteria: Unwilling to follow the study protocol A median daily step count >7,500 steps per day (as measured by the ActiGraph) Cognitive impairment (defined as Montreal Cognitive Assessment, MoCA <22 points) Self-reporting a history of inflammatory bowel disease/syndrome, major depression, bipolar, schizophrenia, or other psychotic disorders Self-reporting type 1 or type 2 diabetes Allergic to intervention or control products Recent use (within the last 3 months) of antibiotics Recent use (within the last 3 months) of pro-biotics Current substance use disorder (Drug Abuse Screening Test, DAST-10>2 points) Current alcohol use disorder (Alcohol Use Disorders Identification Test - Consumption, AUDIT-C≥4 points) Unstable anti-depressant use (e.g., change in medication within last 3-6 months) Current homicidal or suicidal ideation (assessed via the P4 Suicidality Screener) Current psychosis (via the Psychosis and Hallucinations Questionnaire, PHQ>12 points) Manic symptoms (assessed by the Mood Disorder Questionnaire, MDQ >5 points)
Sites / Locations
- Hebrew Rehabilitation CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Freeze-dried Blueberry Powder
Placebo Powder
Randomized participants will be asked to consume 48 grams of freeze-dried blueberry powder each day for 12 weeks.
Randomized participants will be asked to consume 48 grams of a nutritionally matched placebo powder devoid of fiber and anthocyanins each day for 12 weeks.