Network Control TMS fMRI
Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, Working Memory
About this trial
This is an interventional basic science trial for Attention Deficit Hyperactivity Disorder focused on measuring TMS, memory, ADHD, healthy, MRI, ADD
Eligibility Criteria
Inclusion Criteria: 18-28 years old Right-handed No history of schizophrenia or bipolar disorder No history of neurological illness Healthy participants: no history of any mental illness ADD/ADHD Participants; Diagnosed with ADD/ADHD ADD/ADHD: Ability to refrain from stimulant medication within 24 hours of study sessions For participants reporting daily use of more than 400mg caffeine/ day: willing to lower down to this level at least 1 week prior to screening visit and maintain throughout study visits Exclusion Criteria: Unable to have an MRI scan Unable to receive or tolerate TMS Pregnant, nursing, or trying to become pregnant (self-attestation alone) History of stoke, epilepsy, or brain scarring Healthy participants: psychoactive medication use Healthy participants: first degree relative with psychosis ADHD participants: inability to refrain from stimulant medication within 23 hours of study sessions Active suicidality or current suicidal risk as determined by the investigator Any medication that interferes with fMRI recordings as per PI discretion Otherwise determined by investigator to be unfit for study
Sites / Locations
- University of PennsylvaniaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Experimental
High regional controllability TMS target in non-symptomatic participants
Low controllability TMS target in non-symptomatic participants
High regional controllability TMS target in ADHD participants
We will administer TMS to an individualized target of high regional controllability while non-symptomatic participant completes a working memory task inside the MRI scanner.
We will administer TMS to an individualized target of low regional controllability while non-symptomatic participant completes a working memory task inside the MRI scanner.
We will administer TMS to an individualized target of high regional controllability while patient completes a working memory task inside the MRI scanner.