Pain and Microbial Reduction of Antimicrobial Corticosteroid Mixture Versus Cryotherapy in Necrotic Teeth (MIXCRYO)
Dental Pulp Necrosis
About this trial
This is an interventional treatment trial for Dental Pulp Necrosis focused on measuring Antibiotic, Antifungal, Corticosteroid, Cryotherapy
Eligibility Criteria
Inclusion Criteria: Patients in good physical health; American Society of Anesthesiologists class I or II. Patients whose age ranges between 18 and 50 years. Male and female patients. Patients having a single canal-tooth with necrotic pulp. Patients who can understand the number rating scale (figure). Patients who accept to participate in the trial and can sign the informed consent (figure). Exclusion Criteria: Pregnant females. Patients with swelling. Patients whose tooth is non-restorable. Teeth with open apices. Teeth with radiographic evidence of root resorption.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Antimicrobial Corticosteroid mixture
Cryotherapy
Each canal will receive 5 minutes of final irrigation with the antimicrobial-corticosteroid solution of a freshly prepared mixture of: 1 ml of Levofloxacin (Tavanic, Sanofi Aventis, Egypt). 1 ml of Fluconazole (Sunny fungal, Sunny pharmaceuticals, Egypt). 1 ml of Dexamethasone sodium phosphate (Dexamethasone, Amriya, Egypt).
Each canal will receive final irrigation with 20ml of cold saline (2.5°c) for 5 minutes.