Analgesic Additives to Epidural Bupivacaine in Normal Labor
Labor Pain
About this trial
This is an interventional supportive care trial for Labor Pain focused on measuring epidural anathesia, normal labor
Eligibility Criteria
Inclusion Criteria: >/= 18 years of age American Society of Anesthesiologists (ASA) Physical Status 2 or 3 Full term pregnancy (>37 gestational weeks) Planning vaginal delivery Planning epidural labor analgesia Vertex presentation Exclusion Criteria: Patient refusal to epidural analgesia, Contraindications of epidural analgesia (coagulopathy, local infection, vertebral deformity) Allergy to study agents (hypersensitivity to bupivacaine, Nalbuphine, fentanyl or dexmedetomidine) hemodynamic instability, severe aortic or mitral stenosis) Severe pre-eclampsia, Breech presentations Antepartum hemorrhage Cephalopelvic disproportion Body mass index ≥40 kg/m2. Uncontrolled systemic comorbidities [i.e., diabetes, hepatic, renal or cardiac] Known or suspected fetal abnormalities Inability to communicate or participate in study procedures
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
epidural Bupivacaine with Dexmedetomidine in normal labor
epidural Bupivacaine with fentanyl in normal labor
epidural Bupivacaine with Nalbuphine in normal labor
Epidural analgesia will be initiated and maintained using a solution of 0.125% bupivacaine with Dexmedetomidine 0.5 μg/ml
Epidural analgesia will be initiated and maintained using a solution of 0.125% bupivacaine with fentanyl 2 μg/ml.
Epidural analgesia will be initiated and maintained using a solution of 0.125% bupivacaine with 0.2 mg/ml Nalbuphine.