Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury (GH-MTJ)
Muscle Injury
About this trial
This is an interventional basic science trial for Muscle Injury
Eligibility Criteria
Inclusion Criteria: Healthy men and women scheduled to undergo reconstructive knee surgery BMI 18-35 Exclusion Criteria: Former or current use of growth hormone or anabolic steroids Use of corticosteroids in the past 3 months Use of any medication known to affect muscle or tendon turnover Former participation in a study using deuterated water Chronic diseases
Sites / Locations
- Bispebjerg HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Placebo Comparator
1) Electrical stimulation + growth hormone
2) Electrical stimulation
3) Growth hormone
4) Control
One bout of electrical stimulation with 200 eccentric contractions. This is followed by daily injections with somatropin (33.3 ug/kg in the first week, 50 ug/kg in the second week) for two weeks.
One bout of electrical stimulation with 200 eccentric contractions
Daily injections with somatropin (33.3 ug/kg in the first week, 50 ug/kg in the second week) for two weeks.
No intervention