Phase I/IIa Study of BR1733 in Subjects With Advanced Cancers

Inclusion Criteria: Sign informed consent voluntarily. Subjects with PTCL, DLBCL or advance solid tumors diagnosed by histology or cytology，whose disease progressed after standard treatment or have no standard treatment. ECOG≤2. Expected survival period ≥ 3 months. Adequate organ function reserve at baseline. Exclusion Criteria: Subjects with symptomatic central nervous system (CNS) metastases or carcinomatous meningitis; Subjects with a history of other primary malignancies within 5 years (except for cured cervical carcinoma in situ, non-melanoma skin cancer, and superficial bladder tumor), subjects with other primary tumors who had no evidence of disease for 5 years or more and did not require treatment could participate in the study; Subjects with any severe uncontrolled disease such as liver disease such as cirrhosis, decompensated liver disease, kidney failure needs for hemodialysis or peritoneal dialysis, etc. Subjects with HIV disease or a positive HIV test; or active hepatitis. Subjects with organ transplantation (apart from keratoplasty) or allogeneic hematopoietic stem cell transplantation. Subjects with impaired or clinically significant cardiac cerebrovascular disease. Subjects known to be allergic to experimental drugs or similar compounds. Subjects known with psychotropic substance abuse, alcohol or drug abuse, or mental disorders. Any previous treatment with other EED inhibitors (e.g., MAK683, FTX-6058, etc.). Females who are pregnant or breastfeeding.