A Clinical Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste for the Relief of Dentine Hypersensitivity in a Chinese Population

Inclusion Criteria: Participant provision of a signed and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the study before any study procedures are performed. Participant who is willing and able to understand and comply with scheduled visits, product usage requirements and other study procedures. A participant in good general, oral and mental health with, in the opinion of the investigator or medically qualified designee, no clinically significant or relevant abnormalities in medical history or upon oral examination, or condition, that would impact the participant's safety, wellbeing or the outcome of the study, if they were to participate in the study, or affect the individual's ability to understand and follow study procedures and requirements. Participant who owns a smartphone with the WeChat application installed. A participant who presents the following oral and dental inclusions will apply at Screening (Visit 1): Self-reported history of tooth sensitivity lasting more than six months but not more than 10 years and experience DH symptoms at least 'once a week' or more frequently (as mentioned in Screening questionnaire). Good general oral health, with a minimum of 20 natural teeth. Minimum of 2 accessible non-adjacent teeth (incisors, canines, pre-molars), preferably in different quadrants, with clinically confirmed DH. Each eligible tooth must meet all of the following criteria: Exposed dentine due to facial/cervical erosion, abrasion or gingival recession (EAR). Modified Gingival Index (MGI) = 0 directly adjacent to the exposed dentine (i.e., the test area) only Clinical mobility = 0. DH as evidenced by qualifying levels of tactile and evaporative (air) sensitivity (tactile threshold less than or equal to [<=] 20 g and Schiff sensitivity score more than or equal to [>=] 2). A participant who presents the following oral and dental inclusions will apply at Baseline (Visit 2): All teeth identified at Screening (Visit 1) as eligible for Baseline assessments will be reassessed for tactile sensitivity first; eligible teeth with Baseline tactile threshold <= 20g will then be re-assessed for evaporative (air) sensitivity. Participants must have a minimum of two non-adjacent, accessible teeth (incisors, canines, pre-molars), preferably in different quadrants, with clinically confirmed DH as evidenced by qualifying levels of tactile and evaporative (air) sensitivity: Tactile threshold <= 20 g at Screening and Baseline Schiff sensitivity score >= 2 at Screening and Baseline. VAS >= 40 mm at Baseline. The clinical examiner will select two 'test teeth' from those eligible teeth which meet the tactile threshold and Schiff sensitivity score criteria at both Screening and Baseline, and the VAS criterion at Baseline. Each test tooth must demonstrate a consistent DH response to the evaporative (air) stimulus at both Screening and Baseline: Screening Schiff sensitivity score = 2 and Baseline Schiff sensitivity score = 2 or Screening Schiff sensitivity score = 3 and Baseline Schiff sensitivity score = 3. Exclusion Criteria: Participant who is an employee of the study site, either directly involved in the conduct of the study or a member of their immediate family; or an employee of the study site otherwise supervised by the investigator; or a sponsor employee directly involved in the conduct of the study or a member of their immediate family. Participant who has participated in, or has participated in, other studies (including non-medicinal studies) involving investigational product(s) within 30 days of Screening (Visit 1). Participant who is participating in, has participated in, a study evaluating a tooth desensitizing treatment within 8 weeks of Screening (Visit 1). Participant who is using, or has used, an oral care product indicated for DH relief within 8 weeks of Screening (Visit 1). Participant will be required to bring their current oral care products to Visit 1 for staff to verify the absence of known anti-sensitivity ingredients and DH claims. Participant who has had a professional de-sensitizing treatment within 8 weeks of Screening (Visit 1). Participant who habitually rinses with water during toothbrushing (self-reported at Screening Visit 1). Participant who seen to rinse with water while brushing with the acclimatization toothpaste during review of their brushing compliance videos at Baseline (Visit 2). Participant with known or suspected intolerance or hypersensitivity to the study products or any of their stated ingredients (or closely related compounds). Participant who is unwilling or unable to comply with product usage instructions or Lifestyle Considerations as described in the protocol. Female participant who is pregnant or intending to become pregnant during the study (self-reported). Female participant who is breastfeeding. Participant with a recent history (within the last year) of alcohol and/or substance abuse. Participant with, in the opinion of the investigator or medically qualified designee, an acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study product administration or may interfere with the interpretation of study results and, in the judgment of the investigator or medically qualified designee, would make the participant inappropriate for entry into this study. Participant taking daily doses of medications or traditional herbal treatments which, in the opinion of the investigator or medically qualified designee, could interfere with their perception of pain. Examples of such medications include analgesics, anticonvulsants, antihistamines that cause marked or moderate sedation, sedatives, tranquilisers, anti-depressants, mood altering and anti-inflammatory drugs. Examples of herbal treatments include clove oil, olive oil or other treatments directly applied to the oral cavity for the treatment of oral health conditions. Participant taking daily doses of a medication which, in the opinion of the investigator or medically qualified designee, is causing xerostomia. Participant who requires antibiotic prophylaxis for dental procedures. At Screening (Visit 1): participant who has taken antibiotics within 2 weeks of their Screening visit. At Baseline (Visit 2): participant who has taken antibiotics within 2 weeks of their Baseline visit (during the acclimatisation period). Participant who has had a professional or self-applied tooth bleaching procedure within 8 weeks of Screening (Visit 1). Participant who has had dental prophylaxis within 4 weeks of Screening (Visit 1). Participant who has had treatment for periodontal disease (including surgery) within 12 months of Screening (Visit 1). Participant who has had scaling or root planning within 3 months of Screening (Visit 1). Participant with a tongue or lip piercing. Participant with, in the opinion of the investigator or medically qualified designee, gross periodontal disease. Participant with evidence of gross intra-oral neglect or the need for extensive dental therapy. Participant with a fixed or removable partial prosthesis which, in the opinion of the investigator or medically qualified designee, would impact study outcomes. Participant with multiple dental implants which, in the opinion of the investigator or medically qualified designee, would impact study outcomes. Participant with fixed or removable orthodontic braces/bands or a fixed orthodontic retainer. Participant with specific dentition exclusions for "Test Teeth" are as follows: Tooth with evidence of current or recent caries or reported treatment of decay within 12 months of Screening (Visit 1). Tooth with exposed dentin but with deep, defective or facial restorations. Tooth with full crown or veneer. Tooth adjacent to a bridge abutment or crown which, in the opinion of the investigator or medically qualified designee, would impact study outcomes. Sensitive tooth with contributing aetiologies other than erosion, abrasion or recession to exposed dentine. Sensitive tooth, in the opinion of the investigator or medically qualified designee, not expected to respond to treatment with an anti-sensitivity toothpaste. Participant who has previously been enrolled in this study. Any participant who, in the opinion of the investigator or medically qualified designee, should not participate in the study.