Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis (BEST-DKA)
Diabetic Ketoacidosis
About this trial
This is an interventional treatment trial for Diabetic Ketoacidosis
Eligibility Criteria
Inclusion Criteria: Patients in the ED with a primary diagnosis of moderate to severe DKA for whom both saline and Plasma-Lyte® 148 are considered appropriate fluids Blood glucose level > 14mmol/L pH < 7.25 Serum bicarbonate <15 mmol/L Elevated anion gap > 12mEq/L Ketones positive on finger prick measurements In the judgement of the treating clinician critical care area admission is required Exclusion Criteria: Age less than 18 years Patients who have received more than 2000ml of non study fluid prior to study enrolment Serum Na > 155 or <120 mmol/L Contraindication to either study fluid e.g. previous allergic reaction to Plasma-Lyte® 148 Patients with hyperosmotic hyperglycaemic non-ketotic syndrome Other clinical conditions that preclude large volumes of fluid resuscitation Previous inclusion in BEST-DKA trial
Sites / Locations
- Royal North Shore Hospital
- Redcliffe Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Plasma-Lyte® 148
0.9% sodium chloride
Plasma-Lyte® 148 fluid 1L given intravenously for fluid replacement
Normal saline fluid 1L given intravenously for fluid replacement