Effect on Markers of Cardiovascular, Reproductive and Cancer Risk From Firefighting Training (BIOBRAND3)
Reactive Hyperemia, Micro RNA, Heart Rate Variability
About this trial
This is an interventional basic science trial for Reactive Hyperemia focused on measuring Comet assay, 8-oxodG, PAH CALUX, hydroxyl-PAHs and nitro-PAH metabolites, microRNA, AhR activation, scrotal temperature, core body temperature, urine, serum, blood, follicle-stimulating hormone, inhibin B, EndoPAT
Eligibility Criteria
The participants will be volunteers (both males and females) recruited among conscripts in training in a desirable involved group up to 35 individuals. Inclusion Criteria: legally competent, conscript subjects following a Rescue Specialist Educational course Exclusion Criteria: current smoking status, pregnancy, on prescribed medication, body mass index (BMI) bellow 19 or over 30, alcohol or drug abuse.
Sites / Locations
- The National Research Centre for the Working Environment
- Maria Helena Guerra AndersenRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Experimental
Experimental
Experimental
Baseline session
Firefighting exercises without fire
Firefighting under wood fire
Firefighting under gas fire
Baseline measurements will be performed in the same schedule as measurements in the three other arms. In the baseline session, participants are in classroom before starting any firefighting exercise
Firefighting equivalent work, with exercises performed in a clean environment, without fire (no ambient temperature, soot or smoke). This type of exercise usually precedes or complements the training under real fire conditions.
Firefighting under wood fire, with exposure to ambient heat, smoke and soot. This is the most common training scenario used in the training centres. The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models
Firefighting under gas fire, with exposure to ambient heat, and expectably less smoke and soot than with wood fire. These conditions are used in some Danish training centres, with logistical advantages (ease of turning or putting out the fire and managing the fire fuel) and unknown effect relating to exposure prevention (smoke and soot). The participants will be in teams performing pre-defined tasks (knocking down the fire, moving heavy objects, and searching and rescuing metal stand in models