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Faecal Microbiota Transplantation to Ameliorate Nintedanib-induced Diarrhea in Patients With Idiopathic Pulmonary Fibrosis (BIOFEV)

Primary Purpose

Idiopathic Pulmonary Fibrosis

Status
Not yet recruiting
Phase
Not Applicable
Locations
Italy
Study Type
Interventional
Intervention
Autologous FMT
Placebo FMT
Sponsored by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Idiopathic Pulmonary Fibrosis

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Phase 1 (faecal samples collection) Patients aged ≥18 years when signing the informed consent; Diagnosis of IPF within 4 weeks based on 2018 ATS/ERS/JRS/ALAT Guidelines (2) as confirmed by the investigator based on chest HRCT scan and if available surgical lung biopsy; Patients already on antifibrotic therapy with nintedanib according to clinical practice. Phase 2 (FMT procedure) - Patients who develop diarrhea of grade 2 or 3 according to the Common Terminology Criteria (CTC) for Adverse Events (AE) version 5.0 (12) within 8 weeks of baseline visit. Exclusion Criteria: Women of childbearing potential or pregnant; History of colorectal surgery or cutaneous stoma; Food allergies; Recent (<6 weeks) therapy with drugs that could possibly alter gut microbiota (e.g. antibiotics, probiotics, proton pump inhibitors, immunosuppressants and/or metformin); Any documented active or suspected malignancy, except appropriately treated basal cell carcinoma of the skin, "under surveillance" prostate cancer or in situ carcinoma of uterine cervix; Decompensated heart failure or heart disease with ejection fraction lower than 30%, severe respiratory failure, psychiatric disorders, pregnancy or inability to provide informed consent. Fecal sample unable for FMT according to the opinion of the Investigators (e.g. positive for pathogens); (phase 2 only) Diarrhea from known causes (e.g. infectious gastroenteritis, Clostridium difficile infection, coeliac disease, inflammatory bowel disease, irritable bowel syndrome, chronic pancreatitis and/or biliary salt diarrhea).

Sites / Locations

  • Fondazione Policlinico Agostino Gemelli IRCCS

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Faecal microbiota transplantation

Placebo arm

Arm Description

Outcomes

Primary Outcome Measures

Number of Participants with Resolution of diarrhea
Resolution of diarrhea at 4 weeks from FMT procedures.

Secondary Outcome Measures

Number of Participants with Resolution of diarrhea
Resolution of diarrhea at 1 and 12 weeks from FMT procedures
Nintedanib discontinuation
Rate of nintedanib discontinuation or dose reduction
Intestinal microbiota composition
Analysis of intestinal microbiota composition at baseline and at 1, 4 and 12 weeks after the end of FMT procedures
Forced vital capacity (FVC)
Relative and absolute change in forced vital capacity (FVC) percent-predicted from baseline at week 12
St. George's Respiratory Questionnaire (SGRQ)
Change in St. George's Respiratory Questionnaire (SGRQ) score from baseline at week 12
Exacerbation
Time to first acute exacerbation.

Full Information

First Posted
February 23, 2023
Last Updated
September 1, 2023
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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1. Study Identification

Unique Protocol Identification Number
NCT05755308
Brief Title
Faecal Microbiota Transplantation to Ameliorate Nintedanib-induced Diarrhea in Patients With Idiopathic Pulmonary Fibrosis
Acronym
BIOFEV
Official Title
Faecal Microbiota Transplantation to Ameliorate Nintedanib-induced Diarrhea in Patients With Idiopathic Pulmonary Fibrosis
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Not yet recruiting
Study Start Date
October 2023 (Anticipated)
Primary Completion Date
April 2024 (Anticipated)
Study Completion Date
April 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No

5. Study Description

Brief Summary
This is a multicentric, randomised, double-blind, placebo-controlled study that will consist of two consecutive phases: First phase: faecal samples will be collected in patients diagnosed with Idiopathic pulmonary fibrosis treated with nintedanib. Second phase: double-blind, randomised, clinical trial of autologous faecal microbiota transplantation (FMT) vs placebo in Idiopathic pulmonary fibrosis patients who will experience nintedanib-induced diarrhea within 8 weeks of baseline visit. Follow-up visits will be scheduled at 1, 4 and 12 weeks after randomization. The main aim of the study is to assess the efficacy of FMT in ameliorating diarrhea experienced by patients with idiopathic pulmonary fibrosis treated with nintedanib.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Idiopathic Pulmonary Fibrosis

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
114 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Faecal microbiota transplantation
Arm Type
Experimental
Arm Title
Placebo arm
Arm Type
Placebo Comparator
Intervention Type
Procedure
Intervention Name(s)
Autologous FMT
Intervention Description
Autologous faecal microbiota transplantation by colonoscopy.
Intervention Type
Procedure
Intervention Name(s)
Placebo FMT
Intervention Description
Placebo FMT will consist of 250 mL water. Placebo infusions will be delivered by colonoscopy.
Primary Outcome Measure Information:
Title
Number of Participants with Resolution of diarrhea
Description
Resolution of diarrhea at 4 weeks from FMT procedures.
Time Frame
4 weeks
Secondary Outcome Measure Information:
Title
Number of Participants with Resolution of diarrhea
Description
Resolution of diarrhea at 1 and 12 weeks from FMT procedures
Time Frame
1 and 12 weeks
Title
Nintedanib discontinuation
Description
Rate of nintedanib discontinuation or dose reduction
Time Frame
12 weeks
Title
Intestinal microbiota composition
Description
Analysis of intestinal microbiota composition at baseline and at 1, 4 and 12 weeks after the end of FMT procedures
Time Frame
1, 4 and 12 weeks
Title
Forced vital capacity (FVC)
Description
Relative and absolute change in forced vital capacity (FVC) percent-predicted from baseline at week 12
Time Frame
12 weeks
Title
St. George's Respiratory Questionnaire (SGRQ)
Description
Change in St. George's Respiratory Questionnaire (SGRQ) score from baseline at week 12
Time Frame
12 weeks
Title
Exacerbation
Description
Time to first acute exacerbation.
Time Frame
12 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Phase 1 (faecal samples collection) Patients aged ≥18 years when signing the informed consent; Diagnosis of IPF within 4 weeks based on 2018 ATS/ERS/JRS/ALAT Guidelines (2) as confirmed by the investigator based on chest HRCT scan and if available surgical lung biopsy; Patients already on antifibrotic therapy with nintedanib according to clinical practice. Phase 2 (FMT procedure) - Patients who develop diarrhea of grade 2 or 3 according to the Common Terminology Criteria (CTC) for Adverse Events (AE) version 5.0 (12) within 8 weeks of baseline visit. Exclusion Criteria: Women of childbearing potential or pregnant; History of colorectal surgery or cutaneous stoma; Food allergies; Recent (<6 weeks) therapy with drugs that could possibly alter gut microbiota (e.g. antibiotics, probiotics, proton pump inhibitors, immunosuppressants and/or metformin); Any documented active or suspected malignancy, except appropriately treated basal cell carcinoma of the skin, "under surveillance" prostate cancer or in situ carcinoma of uterine cervix; Decompensated heart failure or heart disease with ejection fraction lower than 30%, severe respiratory failure, psychiatric disorders, pregnancy or inability to provide informed consent. Fecal sample unable for FMT according to the opinion of the Investigators (e.g. positive for pathogens); (phase 2 only) Diarrhea from known causes (e.g. infectious gastroenteritis, Clostridium difficile infection, coeliac disease, inflammatory bowel disease, irritable bowel syndrome, chronic pancreatitis and/or biliary salt diarrhea).
Facility Information:
Facility Name
Fondazione Policlinico Agostino Gemelli IRCCS
City
Rome
State/Province
Roma
ZIP/Postal Code
00168
Country
Italy

12. IPD Sharing Statement

Learn more about this trial

Faecal Microbiota Transplantation to Ameliorate Nintedanib-induced Diarrhea in Patients With Idiopathic Pulmonary Fibrosis

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