Intratendinous Genipin Injection in Horses With Tendon Injuries
Superficial Digital Flexor Tendonitis
About this trial
This is an interventional treatment trial for Superficial Digital Flexor Tendonitis
Eligibility Criteria
Inclusion Criteria: clinical and sonographic evidence of a tendon injury Exclusion Criteria: in the final analysis, only superficial digital flexor tendon injuries were included if follow-up was less than 12 m due to euthanasia, death or other reasons, horses were excluded from the study
Sites / Locations
- Equine surgery, Vetsuisse-Faculty, University of Zurich
Arms of the Study
Arm 1
Experimental
Intratendinous genipin injection
Genipin was administrated intratendinously under sonographic guidance. For lesions up to 3 cm in length, two separate 0.2 ml injections of genipin solution were administered into the region of transition from degenerated to normal tendon tissue. One injection was given at the proximal end of the lesion and the other at the distal end. For lesions longer than 3 cm, an additional 0.2 ml injection was used for every additional 3 cm of lesion length. In the illustrated example, the 6 cm lesion required a total of three injections, and therefore one additional injection was given in the middle of the lesion between the distal and proximal injections. Genipin treatment solution contained 100 mM genipin and 20% of the solvent dimethyl sulfoxidee in phosphate buffered saline. Instead of one administration of a relatively large volume, several individual administrations of 0.2 ml were performed depending on lesion size .