The Efficacy and Safety of Topical Vitamin D and Supplementation In Acne Vulgaris The Study of VDR, IL-1β, IL-6, IL-10 and IL-17 Expression
Acne Vulgaris, Vitamin D
About this trial
This is an interventional treatment trial for Acne Vulgaris
Eligibility Criteria
Inclusion Criteria: Men and women diagnosed with moderate or severe acne vulgaris Aged over 18-50 years. During the study, were willing not to use skin care products either in oral and/or topical form on the face, as well as other treatments outside of standard AV treatment. Willing to take part in the examination and treatment in accordance with the provisions of the study and follow the control time schedule in accordance with the predetermined research plan also willing to sign the informed consent form. Exclusion Criteria: Women who are pregnant and breastfeeding. Have history using topical antibiotics in the past 2 weeks. Have history using topical corticosteroids in the past 2 weeks. Have history taking vitamin D supplements in the last 1 month. Have history taking oral antibiotics in the last 1 month. Have history using oral corticosteroid use in the last 1 month. Have history using oral and topical retinoid use in the last 3 months. Have history using topical BPO in the last 1 month. Using hormonal contraception for women. Have history of drug allergies or skin disorders due to side effects of first-line therapy drugs for moderate/severe acne vulgaris. Impaired liver and kidney function.
Sites / Locations
- RSUPN Dr. Cipto Mangunkusumo
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Placebo Comparator
combination vitamin D oral and topical cholecalciferol
oral placebo and topical vitamin D
oral placebo and basic ingredient placebo topical vitamin D
combination topical vitamin D and supplementation Daily supplementation (1x/day, in the morning) and topical application (2x/day, in the morning and in the afternoon, minimum duration 4 hours on the skin) for 56 days Daily supplementation (1x/day, in the morning) and topical application (2x/day, in the morning and in the afternoon, minimum duration 4 hours on the skin) for 56 days
oral placebo and topical vitamin D Daily supplementation (1x/day, in the morning) and topical application (2x/day, in the morning and in the afternoon, minimum duration 4 hours on the skin) for 56 days
Daily supplementation (1x/day, in the morning) and topical application (2x/day, in the morning and in the afternoon, minimum duration 4 hours on the skin) for 56 days