Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF

Inclusion Criteria: Patient admitted to the hospital with a primary diagnosis of ADHF Patient has signs of volume overload as evidence by a score of ≥ 4 on the EVEREST score Patient with Left Ventricular Ejection Fraction LVEF >15% Patient has compromised response to diuretics NT-proBNP >450 pg/mL if aged <55 years, >900 pg/mL if aged between 55 and 75 years and >1800 pg/mL if aged >75 years Exclusion Criteria: Patient with active DVT or history of DVT Patient has documented or evidence of Renal artery stenosis BMI>35 Kg/m^2 Patient has documented, untreated symptomatic coronary artery disease (CAD) requiring revascularization Patient is in Cardiogenic shock Patient has blood dyscrasia, acute anemia, thrombocytopenia, bleeding diathesis, or coagulopathy Temperature > 38°C, or sepsis, or active systemic infection requiring IV anti-microbial treatment Patient has shown liver cirrhosis or has signs of liver damage