Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults
Atrophy, Disuse, Atrophy, Muscular
About this trial
This is an interventional treatment trial for Atrophy, Disuse
Eligibility Criteria
Inclusion Criteria: Between the ages of 18-30 Free from medical implants in lower extremity that would interfere with low-dose radiation Are not allergic to ultrasound gel or Lidocaine Have no or minimal experience with resistance training (less than 1 training session/week for a 1 year period) Exclusion Criteria: Have been exposed to medically necessary radiation in the past 12 months other than dental x-rays Have known overt cardiovascular or metabolic disease Have a medical condition that would contraindicate participating in an exercise program or donating a skeletal muscle biopsy (e.g. blood clotting disorder, taking blood thinners, etc.) Are undergoing medical treatment for a disease that would interfere physiologically or logistically with study outcomes and/or protocols (e.g. undergoing chemotherapy and/or radiation for cancer treatment) Have consumed supplemental protein, creatine, and/or agents that affect hormone status (e.g. testosterone, growth hormone boosters, etc.) within the previous 2 months.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Resistance Training Preconditioning (PRECON)
Control (CTL)
This group will perform: 6 weeks of lower body focused resistance training 2 weeks of locking brace-induced immobilization of a randomized leg 6 weeks of lower body focused resistance training
This group will perform: 6 weeks of activities of daily living (no training) 2 weeks of locking brace-induced immobilization of a randomized leg 6 weeks of lower body focused resistance training