STICH-3.0 International Trial Consortium (STICH-3)
Coronary Artery Disease, Heart Failure
About this trial
This is an interventional treatment trial for Coronary Artery Disease focused on measuring PCI, CABG
Eligibility Criteria
Inclusion Criteria: Age >18 years LVEF ≤40% Extensive coronary artery disease (typically defined as a British Cardiovascular Intervention Society jeopardy score of ≥6, on a scale from 0 to 12, with higher scores indicating greater extent of disease). Exclusion Criteria: Decompensated heart failure requiring inotropic/adrenergic support, invasive or non-invasive ventilation or intra-aortic balloon pump/ ventricular assist device therapy less than 48 hours prior to randomization; Valvular heart disease or any other cardiac conditions (e.g. LV aneurysm) indicating the need for surgical repair/replacement; Prohibitive bleeding risk or clinical scenario mandating avoidance of long-term dual antiplatelet therapy; Pregnancy; Circumstances likely to lead to poor treatment adherence; STEMI within 72 hours; PCI within 3 months.
Sites / Locations
- Dep of Cardiology, Sahlgrenska University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Percutaneous Coronary Intervention (PCI)
Coronary artery bypass grafting (CABG)
Patients will be revascularized by PCI
Patients will be revascularized by CABG