Investigation of the Effects of Curcumin and Resveratrol Supplements Added to the Mediterranean Diet on Disease Severity and Inflammatory Biomarkers in Patients With Ulcerative Colitis
Ulcerative Colitis
About this trial
This is an interventional treatment trial for Ulcerative Colitis focused on measuring Ulcerative Colitis, Mediterranean diet, Curcumin, Resveratrol, inflammatory bowel disease
Eligibility Criteria
Inclusion Criteria: Male and female patients aged >18 years, Those previously diagnosed with ulcerative colitis and/or newly diagnosed with clinical course, consistent histology and endoscopy by a gastroenterologist, Mild and Moderate activity disease was confirmed by the Truelove-Witts Severity Index, Using a fixed dose of 5 - aminosalicylic acid (mesalazine) and/or azathioprine, Who did not receive nutrition therapy in the last 3 months, Not using anti-inflammatory drugs and antibiotic drugs in the last 4 weeks, Not using curcumin and resveratrol supplements before participating in the study, Agreeing to participate in the study voluntarily, Exclusion Criteria: Women during pregnancy or lactation Not meeting the inclusion criteria, History of chronic disease (such as diabetes), hypothyroidism and hyperthyroidism, liver, kidney and cardiovascular diseases, polycystic ovary syndrome and Cushing's syndrome, Taking one of the anti-inflammatory and antibiotic drugs,
Sites / Locations
- Inonu University Turgut Ozal Medical CenterRecruiting
- Malatya Training and Research HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Mediterranean Diet
Curcumin Supplementation
Resveratrol Supplementation
The individuals in this group will be given a nutrition model in accordance with the Mediterranean Nutrition Program under the supervision of a dietitian for 8 weeks. Individuals will be informed about the Mediterranean diet, their questions will be answered, the current food consumption record will be examined by the dietitian and they will be asked to follow the nutrition program prepared in the most appropriate way (by considering energy, nutrient requirements and nutritional habits). Every 15 days, the nutrition program will be updated with the meetings to be made by the dietitian and the patient, and the applicability of the program will be checked through daily communication.
In addition to the Mediterranean Diet program in the 1st group for individuals in this group; 800 mg of curcumin supplement (VeNatura Curcumin Supplementary Food, Vefa, Istanbul, Turkey) will be given as 1 capsule each in the morning and evening meals.
In addition to the Mediterranean Diet in the 1st group for individuals in this group; 250 mg resveratrol supplement (VeNatura Resveratrol Supplementary Food, Vefa, Istanbul, Turkey) will be given as 1 capsule each in the morning and evening meals.