Identify the Optimal TMS Target to Modulate Reward Activity
Nicotine Use Disorder
About this trial
This is an interventional treatment trial for Nicotine Use Disorder focused on measuring transcranial magnetic stimulation, reward processing, EEG, neuroimaging
Eligibility Criteria
Inclusion Criteria: Nicotine dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test nicotine dependence score). Be between the ages of 18 and 55 years old. Not received substance abuse treatment within the previous 30 days. Be in stable mental and physical health. If female, test non-pregnant. No evidence of focal or diffuse brain lesion on MRI. Be willing to provide informed consent. Be able to comply with protocol requirements and likely to complete all study procedures. Exclusion Criteria: Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia). Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for > 15 minutes, implanted electronic device, metal in the head, or pregnancy). History of autoimmune, endocrine, viral, or vascular disorder affecting the brain. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression. uninterruptable central nervous system medication
Sites / Locations
- Rutgers University - NewarkRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Active TMS
Sham TMS
Participants in the active condition will receive repetitive TMS (rTMS), delivered at 110% of participants' resting motor threshold at 10 Hz continuously over the predefined prefrontal target for a total of 1000 pulses. Within each of the two TMS sessions, two targets will be stimulated.
Identical parameters will be applied to the SHAM group with the exception that the TMS coil will be flipped 180º to mimic auditory stimulation.