A Study of Mirikizumab (LY3074828) in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT-URGE)
Ulcerative Colitis, Ulcerative Colitis Chronic
About this trial
This is an interventional treatment trial for Ulcerative Colitis
Eligibility Criteria
Inclusion Criteria: Have an established diagnosis of UC for ≥3 months Have confirmed diagnosis of moderately for severely active UC Have current bowel urgency Have demonstrated an inadequate response to, a loss of response to, or an intolerance to conventional or to biologic/Janus Kinase (JAK) inhibitor/sphingosine-1-phosphate (S1P) receptor modulator therapy for UC. Exclusion Criteria: Have Crohn's disease (CD) Have inflammatory bowel disease-unclassified, formerly known as indeterminate colitis, or Have ulcerative proctitis, disease limited to the rectum, that is, distal to the recto-sigmoid junction, which lies approximately 10 to 15 centimeter (cm) from anal verge. Have an inherited immunodeficiency syndrome or a monogenic cause of UC-like colonic inflammation Have any history or current evidence of cancer of the gastrointestinal tract Have active tuberculosis Have HIV infection.
Sites / Locations
- East View Medical Research, LLC
- Dedicated Clinical Research
- Arizona Digestive Health - Sun City
- Arizona Digestive Health - Sun City
- Om Research, LLCRecruiting
- Clinical Applications Laboratories, Inc.
- Sweet Hope Research Specialty, Inc.
- Encore Borland-Groover Clinical ResearchRecruiting
- Advanced Research Associates, LLC
- GCP Clinical Research, LLC
- GCP Clinical Research, LLC
- International Center for Research LLC
- International Center for Research LLC
- Digestive Healthcare of GeorgiaRecruiting
- Atlanta Center for Gastroenterology, P.C.
- Gastroenterology Health Partners
- Gastroenterology Health Partners
- Cotton-O'Neil Clinical Research Center, Digestive HealthRecruiting
- GI Alliance/ Metairie
- Care Access
- Chevy Chase Clinical Research
- Gastro Center of Maryland LLC
- Gastro Center of Maryland LLC
- Clinical Research Institute of Michigan, LLCRecruiting
- MNGI Digestive Health, ATTN: Clinical Research
- NY Scientific
- Digestive Health Partners - Research DepartmentRecruiting
- Charlotte Gastroenterolgy & Hepatology
- Wilmington Medical ResearchRecruiting
- Optimed Research, LTDRecruiting
- Care Access - Youngstown
- Central Sooner ResearchRecruiting
- Gastroenterology Center Of The Midsouth
- Galen Medical Group
- Tri-Cities GastroenterologyRecruiting
- Clinical Trial Network
- Houston Endoscopy And Research Center, LLCRecruiting
- Biopharma Informatic, LLCRecruiting
- Citrine Institute for Research and Wellness
- Citrine Institute for Research and Wellness
- LinQ Research, LLCRecruiting
- LinQ Research, LLCRecruiting
- Gastroenterology Associates of Texas - Denise Rodriguez
- Tyler Research Institute, LLC
- GI Alliance Research Webster
- GI Alliance Research Webster
- Care Access Research LLC - Salt Lake CityRecruiting
- Charlottesville Medical ResearchRecruiting
- Washington Gastroenterology
- Washington Gastroenterology dba GI Alliance
- West Michigan Clinical Research CenterRecruiting
- Medical University of Innsbruck
- Landeskrankenhaus Salzburg, Innere Medizin I, Labor im Erdgeschoss
- AKH Wien- Universitätsklinik für Innere Medizin III Klinische Abteilung für Gastroenterologie & Hepatologie
- Universitair Ziekenhuis Gent - Gastro IBD
- UZ Leuven - E507 Studies IBD tav Tine Hermans
- University Hospital - London Health Sciences Centre
- Vojenska nemocnice Brno, Interni oddeleni
- GastroJeka s.r.oRecruiting
- FN Ostrava, Interní Klinika
- Hepato-Gastroenterologie HKRecruiting
- MUDr. Gregar, s.r.o.Recruiting
- SurGal clinic s.r.o.Recruiting
- PreventaMedRecruiting
- CHU Bordeaux - Hôpital Haut-LévêqueRecruiting
- CHU Rennes - Hôpital Pontchaillou
- Centre Hospitalier de Pau
- Chu Besancon
- Chu Besancon
- Hospices Civils de Lyon - Hôpital Lyon Sud - ARC HGE bâtiment 3I
- CHU Nantes
- CHU Nantes
- Clinique Jules Verne
- Unité de Recherche Clinique (4èmeB)
- Chu de Reims - Hôpital Robert Debré
- CHU de Saint-Etienne
- Chru Nancy Brabois
- Universitätsklinikum Halle (Saale), Universitätsklinik und Poliklinik für Innere Medizin I
- Praxis Dr. M. Mross - Gastroenterologie
- DRK Kliniken Berlin Westend, Gastroenterologie, Studienbüro
- Universitätsklinikum Leipzig, Med. Klinik II
- Clinepert kft
- Semmelweis Egyetem, Belgyógyászati es Hematológiai Klinika
- Semmelweis Egyetem, Belgyógyászati es Hematológiai Klinika
- BMKK-Dr Rethy Pal Tagkórház, Gasztroenterológia
- Debreceni Egyetem Klinikai Központ Gasztroenterológia Klinika
- Clinfan Ltd. Gastroenterology Clinic
- Javorszky Odon Korhaz
- Javorszky Odon Korhaz
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
- IRCCS Saverio de Bellis, National Institute of Gastroenterology
- Azienda Ospedaliero Universitaria Mater Domini - U.O. Fisiopatologia Digestiva
- Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico
- Irccs Ospedale San Raffaele, Gastroenterologia/Ibd Unit, Settore G Piano -1
- Azienda Ospedale Università di Padova
- Fondazione Policlinico Agostino Gemelli IRCCS_ CEMAD
- Uoc Gastroenterologia - Policlinico Tor Vergata
- IRCCS Istituto Clinico Humanitas- Centro Malattie Infiammatorie Intestinali
- A.O.Ordine Mauriziano, SC Gastroenterologia, ambulatorio endoscopia digestiva
- Soc Gastroenterologia
- Solumed Centrum Medyczne
- NZOZ Centrum Medyczne KERmed
- Vitamed Galaj I Cichomski sp.j.Recruiting
- Vitamed Galaj I Cichomski sp.j.Recruiting
- Nzoz All Medicus
- Centrum Medyczne Plejady
- KRAKOWSKIE CENTRUM MEDYCZNE Sp. z o.o
- Topolowa Medicenter Ryszawa & Wspólnicy Sp.j.
- IP Clinic
- Med-GASTR SP. Z O.O., SP.K.
- AmiCare Sp. z o.o. Sp. K.
- Bonifraterskie Centrum Medyczne sp. z o.o
- Allmedica Badania Kliniczne Sp. z o.o. Sp. k.
- Twoja Przychodnia Opolskie Centrum Medyczne
- Nowe Zdrowie-Ck, Kiełtucki I Wspólnicy Sp. J.
- DC-MED Sp. z o.o. s.k.
- Twoja Przychodnia - Szczecinskie Centrum Medyczne
- Sonomed Sp. z o.o.
- NZOZ FOR MED sp. z o.o.
- FutureMeds sp. z o. o.
- Centrum Medyczne Kuba Med 2 Sp. z o.o. ETG Zamosc
- MZ Badania Słowik Zymła Sp.j.
- Fakultná nemocnica s poliklinikou F. D. Roosevelta Banská Bystrica gastroenterologická ambulancia, II. Interná klinika SZU
- CLINIQ, s.r.o
- GASTRO AMBULANCIA, poliklinika ŤahanovceRecruiting
- KM Management, spol. s.r.o
- KM Management, spol. s.r.o
- Fakultna nemocnica Nitra, Interna klinika
- Accout Center s.r.o.
- Accout Center s.r.o.
- Fairfield General Hospital
- King's College Hospital NHS Foundation Trust
Arms of the Study
Arm 1
Experimental
Mirikizumab
Participants will receive mirikizumab intravenously (IV) and mirikizumab subcutaneously (SC).