Effect of APRV and LTV on Lung Ventilation and Perfusion in Patients With Moderate-to-severe ARDS
Acute Respiratory Distress Syndrome
About this trial
This is an interventional treatment trial for Acute Respiratory Distress Syndrome
Eligibility Criteria
Inclusion Criteria: Patients aged ≥18 and ≤80 years; Moderate-to-severe ARDS patients according to the Berlin definition; Endotracheal mechanical ventilation ≤48 h before enrollment; Expected to require continuous invasive mechanical ventilation ≥72 h. Exclusion Criteria: Severe chronic obstructive pulmonary disease, severe asthma, pulmonary bulla, subcutaneous emphysema, mediastinal emphysema, etc; Contraindications to the use of electrical impedance tomography (e.g., chest surgical wounds dressing or presence of pacemaker); Pulmonary interstitial lesions; End-stage of chronic disease, with an expected survival period of <6 months; Body mass index >35 kg/m2; Refractory shock; Intracranial hypertension; Pregnant and parturient woman; Intra-abdominal pressure persisted > 20 mmHg and could not be relieved within 24 hours; Severe thoracic deformity; Severe cardiac dysfunction; Atrial fibrillation and other malignant arrhythmias that seriously affect cardiac output; Pulmonary embolism; Extracorporeal membrane oxygenation is needed; Prone positioning was performed before randomization; Patients who have participated in other clinical trials within 30 days; Patients who have not signed informed consent.
Sites / Locations
- Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
APRV Group
LTV Group
Patients with moderate-to-severe ARDS were supported with APRV.
Patients with moderate-to-severe ARDS were supported with LTV.