Effects of Remote Ischemic Conditioning on Bimanual Skill Learning and Corticospinal Excitability in Children With Unilateral Cerebral Palsy (RIC)
Unilateral Cerebral Palsy
About this trial
This is an interventional treatment trial for Unilateral Cerebral Palsy
Eligibility Criteria
Inclusion Criteria: Children diagnosed with unilateral cerebral palsy (UCP) Manual Ability Classification System (MACS) levels I-III Ability to complete a stack of 3 cups in 1 minute Mainstream in school Exclusion Criteria: Children with other developmental disabilities such as autism, attention deficit hyperactivity disorder, developmental coordination disorders, etc. Children with absent active motor threshold Children with known cardiorespiratory, vascular, and metabolic disorders Children with neoplasm and hydrocephalus Children who are currently receiving or received other adjunct therapies such as rTMS and tDCS in the past 6 months Children with seizures within last 2 years and on anti-seizure medications Children with metal implants and incompatible medical devices
Sites / Locations
- Dept. of Physical Therapy, East Carolina UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Remote Ischemic Conditioning (RIC)
Sham conditioning
RIC is achieved via blood pressure cuff inflation to at least 20 mmHg above systolic blood pressure to 250 mmHg on the more involved arm. RIC involves 5 cycles of 5 minutes blood pressure cuff inflation followed by alternating 5 minutes of cuff deflation and requires 45 minutes. RIC is performed on visits 1-7.
Sham conditioning is achieved via blood pressure cuff inflation to 25 mmHg on the more involved arm. RIC involves 5 cycles of 5 minutes blood pressure cuff inflation followed by alternating 5 minutes of cuff deflation and requires 45 minutes. RIC is performed on visits 1-7.